清香散对脾胃湿热证大鼠模型P物质、生长抑素含量的影响  

Influence of Qingxiang San on Substance P,Somatostatin in Rats Model with the Spleen and Stomach Wet Heat Syndrome

作　　者：谭永振[1] 文小敏[1] 陈佩婵[1] 李玉静[1] 陈佩虹[1] 黄桂琼[1] 

机构地区：[1]南方医科大学中医药学院,广东广州510515

出　　处：《中药材》2008年第10期1526-1528,共3页Journal of Chinese Medicinal Materials

基　　金：广东省中医药局资助课题(2060130)

摘　　要：目的:观察清香散对脾胃湿热证大鼠模型胃窦P物质(Substance P,SP)、生长抑素(Somatostatin,SS)含量的影响。方法:将24只大鼠随机分成3组:正常对照组、湿热组、清香散组,每组各8只,湿热组与清香散组采用肥甘饮食、湿热环境及病原微生物等复合因素建立脾胃湿热证的动物模型。以放免法检测各组大鼠胃窦中SP、SS的变化。结果:湿热组大鼠胃窦SP、SS含量较正常对照组明显降低(P(0.01);清香散组与湿热组比较,SP、SS的含量提高(P(0.01);清香散组与正常对照组比较,SP含量亦有明显提高(P(0.01),而SS的含量与正常对照组比较,差异无显著性意义(P(0.05),说明清香散能提高已降低的SP、SS的含量。结论:脾胃湿热证大鼠模型存在胃肠激素的紊乱,SP、SS含量降低,而清香散对大鼠胃窦的SP、SS含量具有调节作用,能提高已降低的SP、SS的含量。Objective： To observe the influence of Qingxiang San（QS） on substance P（SP） , somatostatin（SS） in rats model of spleen and stomach wet heat syndrome. Methods： 24 rats were divided into 3 groups （each group 8 rats） randomly： the normal control group（NCG） , wet heat group（WHG） ,QS group（QSG）. We set up the spleen and stomach wet heat syndrome of rats model by the composite factors such as greasy and sweet food, wet and hot environment,pathogen and so on. Then the contents of SP,SS were detected by radioimmuno assay. Results： The content of SP, SS in WHG were obviously lower than NCG（P 〈 0. 01 ） ; QSG compared with WIAG, the content of SP, SS increased（ P 〈 0.01 ） ; The content of SP obviously increased when QSG compared with NCG（ P 〈 0.01 ） ; About the content of SS, there was no significant difference between QSG and NCG（ P 〉 0. 05 ）, illustrating that QS can increase the content of SP, SS which had decreased. Conclusion ： QS can regulate the content of SP and SS and increase them which had decreased.

关 键 词：脾胃湿热 清香散 P物质 生长抑素 胃肠激素 

分 类 号：R285.5[医药卫生—中药学]