山丹酮缓释片的制备工艺研究  

Research on Preparation of Shandantong Sustained-Release Tablets

作　　者：原文鹏 刘林娜 王敏[1] 

机构地区：[1]深圳市人民医院/暨南大学第二临床医学院,广东深圳518020

出　　处：《中药材》2008年第10期1564-1567,共4页Journal of Chinese Medicinal Materials

基　　金：深圳市科技计划项目(200404016)

摘　　要：目的:优选制备山丹酮缓释片的最佳工艺。方法:分别以山楂总黄酮和丹参酮为考察指标,运用正交实验法优选;同时采用包合技术和亲水性骨架材料制备缓释片。结果:山楂总黄酮的最佳提取工艺为A2B2C1,丹参酮的最佳提取工艺为A3B1C2,制剂选用亲水性凝胶HPMC以及丙烯酸树脂为骨架材料。结论:经方差分析乙醇浓度和渗漉速度对提取效果有显著性影响,该缓释片的工艺和处方是合理可行的。Objective ： To optimize the preparation of Shandantong sustained-release tablets. Methods ： We used the orthogonal experiment to optimize the preparation and determined the contents of Shanzha total flavonoids and tanshinone. Involved technology and hydrophilicity skeleton materials were adopted to prepare the sustained-release tablets. Results ： The best extracted progress of Shanzha total flavonoids and tanshinone were A2 B2C1 and A3 B1 C2, respectively. The hydrophilicity skeleton materials were gel HPMC and aciylic resin. Conclusions ： The concentration of alcohol and percolated speed are significant factors on the extracted efficacy by analysis of variance. The preparation and prescription of this sustained-release tablet is reasonable.

关 键 词：山楂总黄酮 丹参酮 正交实验 提取工艺 缓释片 

分 类 号：R283[医药卫生—中药学]