黄芩苷对大鼠离体小肠及胃平滑肌条收缩性的影响  

Effects of Baicalin on the Contractility of Intestine and Gastric Strips of Rat

作　　者：徐志立[1] 林原[1] 张厚利[1] 陈大朋[1] 李传勋[1] 唐泽耀[1] 

机构地区：[1]大连医科大学药学院,辽宁大连116044

出　　处：《时珍国医国药》2008年第10期2323-2324,共2页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(No.30772601)

摘　　要：目的研究黄芩苷对大鼠离体小肠及胃平滑肌条收缩性的影响。方法以大鼠离体小肠及胃平滑肌条收缩性为研究模型，考察黄芩苷在高钙、低钙及正常克氏液中对平滑肌条收缩作用的影响；在正常克氏液中分别观察黄芩苷对新斯的明、乙酰胆碱、组胺及阿托品存在下平滑肌收缩性的影响。结果在高钙、正常钙及低钙不同条件下，黄芩苷在6．25～100μmol／L范围内均剂量依赖性抑制小肠、胃平滑肌收缩，拮抗新斯的明、乙酰胆碱及组胺引起的收缩作用，且相加阿托品引起的抑制收缩作用。结论黄芩苷对小肠、胃平滑肌收缩具有明显抑制作用。Objective To investigate the effects of baicalin on the contractility of isolated intestine and gastric smooth muscle strips of rat. Methods The effects of baicaliu on the contractility of isolated rat intestine and gastric strips were studied in Krebs ＇solution in the presence of high, normal and low concentrations of Ca^2＋ respectively. The observation of the effects of baicalin on the contractile activity in the presence of neostigmine, acetylcholine, histamine and atropine respectively were also studied. Results Baiealin inhibited the muscle contraction of isolated rat intestine and gastric strips in a dose - dependent manner, antagonized the stimulation induced by neostigmine, acetylcholine and histamine. Synergy inhibition on contractile activity was induced by concurrent use of baicalin and atropine. Conclusion Baicalin has prominent inhibition on the contractile activity of isolated rat intestine and gastric strips.

关 键 词：黄芩苷 平滑肌条 拮抗作用 相加作用 

分 类 号：R962[医药卫生—药理学]