疏风活络片急性毒性实验研究  

Study on the Acute Toxicity of Shufeng Huoluo Pills

作　　者：安飞云[1] 刘新民[1] 潘新亮[1] 许娟[1] 

机构地区：[1]中南大学,湖南长沙410078

出　　处：《时珍国医国药》2008年第10期2482-2483,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的阐明疏风活络片急性毒性作用的主要组分,以及其他组分对马钱子急性毒性的影响。方法含马钱子的疏风活络片、单纯马钱子以及不含马钱子的疏风活络片分别灌胃染毒昆明小鼠,采用Bliss计算相应的LD50。结果含马钱子的疏风活络片的主要急性毒性表现为抽搐强直性痉挛,与马钱子急性中毒症状相似。含马钱子的疏风活络片的LD50为1253.5 mg/kg,单独马钱子的LD50为489 mg/kg,不含马钱子的疏风活络片LD50>9600 mg/kg。结论马钱子是疏风活络片急性毒性作用的主要成分,疏风活络片复方中其他组分能部分降低马钱子的急性毒性作用。Objective To clarify the main component of acute toxic effect in Shufeng Huoluo pills, and the effects of other components from Shufeng Huoluo pills on acute toxic effect of Semen Strychni. Methods Shufeng Huoluo pills （ contain Semen Stryehni）, Semen Strychni and Shufeng Huoluo pills （not contain Semen Stryehni） were respectively given KM mites by gavage, Bliss method was used to calculate LD50. Results Acute toxic manifestations of Shufeng Huoluo pills （ contain Semen Strychni ） were twitch, entasia, which resemble acute toxic symptoms of Semen Stryehni. LD50 for Shufeng Huoluo pills （contain Semen Stryehni） and Semen Strychni were respectively 1253.5 mg/kg and 489 mg/kg, LD50 for Shufeng Huoluo pills （not contain Semen Strychni） was more than 9 600 mg/kg. Conclusion Semen Strychni was the main acute toxic component of Shufeng Huoluo pills, whereas acute toxic effects of Semen Strychni can be partly decreased by other components of Shufeng Huoluo pills.

关 键 词：疏风活络片 马钱子 急性毒性 LD50 

分 类 号：R285.5[医药卫生—中药学]