基质金属蛋白酶与肌腱重塑  

Matrix metalloproteinases and tendon remodeling

作　　者：张林[1] 宋冰[2] 李敏[3] 

机构地区：[1]苏州大学体育学院,江苏苏州215021 [2]湛江教育学院体育系,广东湛江524037 [3]商丘师范学院体育系,河南商丘476000

出　　处：《体育学刊》2008年第10期103-108,共6页Journal of Physical Education

基　　金：江苏省社会发展项目(BS2006020)

摘　　要：基质金属蛋白酶是降解肌腱细胞外基质蛋白的重要蛋白酶,在肌腱重塑中具有重要的作用。一些基质金属蛋白酶对保持肌腱的健康是必需的,而另一些可能会导致肌腱的损伤。目前研究表明机械负载、炎性因子影响腱细胞中基质金属蛋白的表达和活性,共同作用于腱细胞时具有协同或抑制效应。适当运动可使肌腱发生重塑,改善其力学性能、生化组成及结构。Metalloproteinases are a large family of enzymes capable of degrading all of the tendon matrix components, and these are thought to play a major role in the degradation of matrix during tendon remodeling. Some metalloproteinase enzymes are required for the health of the tendon, and others may be damaging, leading to degenera- tion of the tissue. Now researches indicated mechanical loading and cytokines can regulate MMPs expression and activity, and there is a synergetic or inhibitory effect between them. Exercise leads to tendon remodeling, changing its biomechanical, biochemical and structural properties.

关 键 词：基质金属蛋白酶 肌腱重塑 细胞外基质 综述 

分 类 号：G804.7[文化科学—运动人体科学]