β2肾上腺素能受体基因G(+252)A多态性与新疆哈萨克族原发性高血压的相关研究  

The relationship between the G(+252)A polymorphism of β2-adrenergic receptor gene and essential hypertension in Kazaks of Xinjiang

作　　者：刘克坚[1] 周玲[2] 杨进[2] 李涛[2] 彭宇明[3] 李南方[2] 

机构地区：[1]石河子大学医学院 [2]新疆维吾尔自治区人民医院高血压诊断治疗中心/自治区人民医院高血压研究所 [3]新疆医科大学,28期研究生新疆乌鲁木齐830001

出　　处：《农垦医学》2008年第5期365-368,共4页Journal of Nongken Medicine

基　　金：自治区科技攻关和重点科技项目200633129(3);国家自然科学基金资助课题30260038

摘　　要：目的:本研究旨在探讨β2肾上腺素能受体基因(β2-adrenergic receptor,β2-AR)编码区+252位碱基G→A多态性与哈萨克族原发性高血压的相关性。方法:以人群为基础的病例-对照研究,选择433例哈萨克族人(276例高血压患者与157例血压正常者)为研究对象,应用PCR-RELP技术,检测β2-AR基因G(+252)A位点基因型,并观察各基因型、等位基因频率在该人群中分布及差异。结果:该人群β2-AR基因G(+252)A位点在高血压组和正常血压组两组中基因型及等位基因频率的分布差异均无统计学意义(P>0.05)。各基因型间年龄、体质指数、收缩压以及舒张压差异无统计学意义(P>0.05)。结论:新疆哈萨克族β2-AR基因G(+252)A多态性可能与高血压无相关性。Objective： To study the relationship between the G（ ＋ 252）A polymorphism of β2 - AR gene and essential hypertension in Kazaks of Xinjiang.Methods： In this population-based case- control study, we recruited 433 Kazakns subject（276 hypertensives and 157 normotensives） from the pastoral areas in Xinjiang. The genotypes of β2 - AR was identified by PCR - restriction fragment length polymorphism in all the subjects. The distributiong of genotypic and allelic frequencies between hypertensives and normotensives were studied. Results： In the population, there was no significant difference in the distribution of genotypes and allele frequency of G（ ＋ 252 ） A polymorphisms between these two greups（ P 〉 0.05 ）. In addition, age, body mass index, systolic blood pressure and diastolic blood pressure had no significant difference in the groups classified according to genotypes （ P 〉 O. 05 ）. Conclusion： G（ ＋ 252）A polymorphism of β2- AR gene was not related with essential hypertension in Kazaks of XinJiang.

关 键 词：高血压 哈萨克族 Β2-肾上腺素能受体基因 基因多态性 

分 类 号：R544.1[医药卫生—心血管疾病]