革兰阴性杆菌对头孢哌酮/舒巴坦耐药率的变迁  

Prevalence of antimicrobiol-resistant to Cefoperazone/Sulbactam in Gram-negative bacilli

作　　者：王金果[1] 黄海霞[1] 陈坚[1] 余方友[1] 

机构地区：[1]温州医学院附属第一医院实验诊断中心,浙江温州325000

出　　处：《中国微生态学杂志》2008年第5期485-486,488,共3页Chinese Journal of Microecology

摘　　要：目的调查革兰阴性杆菌对头孢哌酮/舒巴坦的耐药率变化。方法收集2004年1月至2007年12月从我院住院患者各种临床标本中分离的革兰阴性杆菌,使用VITEK-60全自动微生物分析仪进行菌种的鉴定,采用K-B法对头孢哌酮/舒巴坦进行药敏试验,对结果进行回顾性调查。结果肠杆菌科细菌对头孢哌酮/舒巴坦的耐药率较低,大肠埃希菌、肺炎克雷伯菌和阴沟肠杆菌对头孢哌酮/舒巴坦的耐药率分别为1.7%,7.7%和5.8%。嗜麦芽窄食假单胞菌、洋葱伯克霍尔德菌、脑膜脓毒性金黄杆菌、铜绿假单胞菌和鲍曼不动杆菌对头孢哌酮/舒巴坦的耐药率分别为27.6%、38.0%、2.3%、23.5%和4.8%。铜绿假单胞菌和鲍曼不动杆菌对头孢哌酮/舒巴坦的耐药率从2004年的35.1%和23.7%下降至2007年的12.4%和0.4%。结论头孢哌酮/舒巴坦对肠杆菌科细菌具有非常强的体外抗菌活性,铜绿假单胞菌和鲍曼不动杆菌对头孢哌酮/舒巴坦的耐药率呈下降趋势。Objective To investigate the prevalence of antimicrobiol-resistant to cefoperazone/Sulbactam in Gram- negative bacilli isolated from clinical specimens from January, 2004 to December, 2007. Methods Gram-negative bacilli were isolated from various clinical specimens in our hosptial from January ,2004 to December,2007. The identification and antimicrobiol susceptiblity test were performed by Vitek-60 Full Automated Microbiology Analyzer. Results The resistance rate of Enterobacteriaceae to cefoperazone/Sulbactam was very low. The resistant rates of Escherichia coli, Klebsiella pneu- moniae and Enterobacter cloacae to Cefoperazone/Sulbactam were 1.7% ,7.7% and 5.8%, respectively. The resistant rates of Stenotrophomortas maltophilia, Burkholderia cepacia, Chryseobacterium rneningosepticurn, Pseudomonas aeruginosa and Acinetobacter baumanii were 27.6% , 38.0% , 2.3%, 23.5% and 4.8% , respectively. The resistant rates of Pseudomonas aeruginosa and Acirtetobacter baumanii to cefoperazone/Sulbaetam decreased from 35.1% and 23.7% in 2004 to 12.4% and 0. 4% in 2007. Conclusion Cefoperazone/Sulbaetam has high antimierobial activity to Enterobacteriaceae. The rates of Pseudomonas aeruginosa and Acinetobacter baurnanii to cefoperazone/Sulbactam decrease gradually.

关 键 词：革兰阴性杆菌 头孢哌酮/舒巴坦 抗菌活性 

分 类 号：R378[医药卫生—病原生物学]