大环四胺镍(Ⅱ)配合物催化羧酸酯的水解反应  

Carboxyester Hydrolysis Catalyzed by Nickel(Ⅱ)Complex of Macrocyclic Quadriamine

作　　者：王敏[1,2] 陶长元[1] 李军[2] 桑雪梅[2] 

机构地区：[1]重庆大学化学化工学院,重庆400030 [2]重庆工学院化学与生物工程学院,重庆400050

出　　处：《重庆工学院学报（自然科学版）》2008年第10期60-63,共4页Journal of Chongqing Institute of Technology

基　　金：重庆市自然科学基金资助项目(2006BB7389)

摘　　要：根据以往文献合成和表征了一种大环四胺镍(Ⅱ)配合物NiR(R:2,3,9,10-四甲基-1,4,8,11-四氮杂环十四-1,3,8,10-四烯高氯酸),元素分析与以往文献一致.首次研究将该配合物作为模拟水解金属酶催化α-吡啶甲酸对硝基苯酚酯(PNPP)的水解反应.结果表明,配合物在催化PNPP水解中表现出良好的催化活性,且活性随体系pH值和温度的增大而增大.根据实验结果,提出了PNPP催化水解的反应机理,分析了PNPP催化水解增速的原因.Based on the literatures concerned, a transitional metal ion macrocyclic complex, NiR （R： 2, 3, 9, 10-quadrimethyl-1, 4, 8, 11 tetraaza-cyclotetradecane-1, 3, 8, 10-quadrialkene perchloric acid） is synthesized and characterized. Metal complex is, for the first time, used as mimetic metal hydrolytic enzyme for the hydrolysis of p-nitrophenyl picolinate （PNPP）. The results indicate that the metal complex shows high activity for the PNPP catalytic hydrolysis in the solution and the activity increases with the rising of pH and temperature of the systems. Based on the experimental results, the mechanism is proposed and the reason for speed increasing is analyzed for PNPP catalytic hydrolysis.

关 键 词：镍配合物 羧酸酯 模拟酶 水解 动力学 

分 类 号：O643.1[理学—物理化学]