阳江高本底地区肺癌与室内氡暴露巢式病例-对照研究  

A nested case-control study of lung cancer risk and residential radon in high background radiation areas of Yangjiang in China

作　　者：王海军[1] 邹剑明[2] 孙全富[1] 袁镛龄[3] 谭光享[2] 杨浩贤[2] 杨宇华[2] 秋葉澄伯[4] 森岛弥重 魏履新[1] 

机构地区：[1]中国疾病预防控制中心辐射防护与核安全医学所,北京100088 [2]广东省职业病防治院,广州510300 [3]湖南省劳动卫生职业病防治所,长沙410007 [4]日本鹿儿岛大学医学部 [5]日本近畿大学原子力研究所

出　　处：《中国职业医学》2008年第5期370-373,共4页China Occupational Medicine

基　　金：中日合作广东阳江高本底地区居民癌症流行病学研究的一个分题;本京都体质研究会的部分资助

摘　　要：目的研究居室氡暴露与肺癌危险的关系。方法采用巢式病例-对照研究设计，病例与对照为1：2个体配比。以面访的方式访问调查对象的家属或其他知情人。用固体核径迹探测器方法，对调查对象曾住房屋的氡浓度进行累积测量。结果成功访问了63例肺癌病例和125例对照，病例与对照的平均死亡年龄分别为60．1岁和60．6岁。病例和对照所在室内氡的平均浓度分别为40．1和39．2Bq／m^3。单因素条件logistic回归分析氡暴露与肺癌危险的关系．比值比[（OR）95％可信限（95％CI）]为1．25（0．63—2．52）。不同程度氡暴露，肺癌危险有增加趋势，但差异无统计学意义（P〉0．05）。在100Bq／m^3氡浓度时，氡暴露的超额比值比（EOR）为0．30（95％CI：-0．53-14．93），调整钍射气贡献后．EOR=0．14。结论未发现室内氡暴露与肺癌危险有统计学意义的关联。Objective To evaluate potential effects on lung cancer associated with the exposure to residential radon in high background radiation areas of Yangjiang in China. Methods A matched nested case-control study was conducted using the data of them died of lung cancer during 1987--1995. Two controls were selected for each case from those who died of other diseases other than malignant tumor and accidental death. Study subjects＇ relatives were face-to-face interviewed using a standardized questionnaire. Radon detectors were placed in all houses having ever been occupied by the subjects to measure cumulative radon concentrations. Results 63 cases and 125 controls were successfully interviewed. The mean death ages of the cases and the controls were 60. 1 and 60. 6 years, respectively. The arithmetic mean of radon concentrations of the cases and the controls were 40. 1 and 39.2 Bq/m^3, respectively. Univariate conditional logistic regression analysis showed that there was no significant difference between the risk of lung cancer and exposure to residential radon（ OR = 1.25, 95% CI： 0. 63 -2. 52）. With the tendency test between different radon concentration levels and the risk of lung cancer, the result showed that there was no significant difference（ P 〉 0.05 ）. At the radon concentration of 100 Bq/m^3 , the excess odd ratio （EOR） of exposure to radon was 0. 30 （95% CI： -0. 53 - 14.93 ） ,and adjusted value of EOR was 0.14 taken into account of the contribution of thoron. Conclusion The study showed that no significant association was observed between the risk of lung cancer and exposure to residential radon.

关 键 词：巢式病例-对照研究 肺癌 氡 高本底地区 

分 类 号：X591[环境科学与工程—环境工程]