TRPC6与肾脏疾病  

TRPC6 and kidney diseases

作　　者：匡新宇[1] 黄文彦[1] 

机构地区：[1]复旦大学附属儿科医院肾内科,上海200032

出　　处：《国际病理科学与临床杂志》2008年第5期456-460,共5页Journal of International Pathology and Clinical Medicine

基　　金：上海市卫生局科研项目(2007-138)~~

摘　　要：瞬时受体电位阳离子通道(transient receptor potential channel,TRPC)作为瞬时受体电位(transientreceptor potential,TRP)超家族中的一员,是一种非选择性的离子通道,在人体的各种组织、器官和细胞中均有表达。TRPC6基因突变致局灶节段性肾小球硬化(focal segmental glomerulosclerosis,FSGS),从而揭示了TRPC通道,尤其TRPC6与肾脏疾病的密切关系。TRPC6突变可引起细胞内钙离子浓度升高,也可直接影响肌动蛋白细胞支架组织,这些都是导致肾脏疾病的机制。Transient receptor potential channel （ TRPC）, which is one of the members of transient receptor potential （TRP） channel, is a nonselective ion channel. It generally distributes in human body, including nervous system, immune system, kidney, lung, spleen, smooth muscle and so on. The mutation of TRPC6 could result in focal segmental glomerulosclerosis （FSGS）, and this suggest a close correlation between TRPC6 and kidney diseases. The mutation of TRPC6 could elevate the intracellular Ca^2＋ concentrations and could directly affect cytoskeletal organization in podocytes.

关 键 词：TRPC6 肾脏 足细胞 蛋白尿 局灶节段性肾小球硬化 

分 类 号：R692[医药卫生—泌尿科学]