卡马西平血药浓度和临床用药的相关性研究  

The Correlation Between Serum Concentrations of Carbamzepine and Rational Use of Drug

作　　者：刘菁华[1] 陈连红[2] 田国力[1] 陆燕芬[2] 陈丽琴[2] 

机构地区：[1]上海交通大学附属儿童医院核医学科,上海200040 [2]上海交通大学附属儿童医院神经科,上海200040

出　　处：《标记免疫分析与临床》2008年第5期282-284,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：研究癫痫患儿卡马西平血药浓度与临床用药的相关性。对年龄1-19岁,服用卡马西平治疗的癫痫患儿185例血样进行检测,采用化学发光免疫分析法测定其稳态血药浓度,并对结果进行统计分析。结果表明,临床服药剂量和血药浓度没有明显的相关性,而年龄对血药浓度有明显的相关性（P〈0.01）。卡马西平血药浓度受多种因素影响,以年龄影响最明显,在持续血药浓度监测的情况下,提倡个体化给药。To analyze the correlation between serum concentrations of carbamzepine and clinical rational use of drug, serum carbamzepine concentrations were measured in 185 children with epilepsy with age ranging from 1 to 19 years old. Homeostasis concentrations were measured with chemiluminesence assay method. The results showed that there was no correlation between medical dosage and serum carbamzepine concentrations. But the ages of patients showed strong correlation with serum carbamzepine concentrations （P〈0.01）. The serum carbamzepine concentrations were affected by many elements in which ages of patients were manifest factors. Individualized usage of drug and monitoring could be suggested in the treatment of children with epilepsy .

关 键 词：癫痫 卡马西平 药物监测 儿童 

分 类 号：R96[医药卫生—药理学]