同步记录无损伤心内、外膜心肌MAP对比研究  

Contrast Research of Non-damage Endo-epicardium Cardiac Muscle MAP Synchronously Recorded

作　　者：肖业伟[1] 何光凤[2] 杭永伦[2] 刘希秀[1] 冯志强[1] 盘强文[1] 

机构地区：[1]泸州医学院生理教研室 [2]泸州医学院附属医院药剂科,四川泸州646000

出　　处：《中国现代医生》2008年第31期49-50,共2页China Modern Doctor

基　　金：四川省教育厅青年基金项目(基金编号:2005B014)

摘　　要：目的建立无损伤同步记录心内外膜心肌MAP技术,比较内外膜MAP差异,更有效的探讨心律失常机制。方法15只家兔,在心肌缺血背景下致心律失常前后分别记录内外膜MAP各项观察指标,作对照比较。结果在心律失常前后,内外膜振幅APD90比较,差异不具有统计学意义(P>0.05);但心律失常前后内外膜间比较,APD50差异具有统计学意义(P<0.05),且外膜APD50在心律失常前后自身比较,统计学有显著差异(P<0.05)。结论成功建立同步记录无损伤心内外膜心肌MAP模型,为探讨心律失常机制建立良好实验平台。Objective To establish a technology to record the endo-epicardium cardiac muscle MAP without damage synchronously and compare the difference between endo-epicardium MAP, to discuss arrhythmogenic mechanism effectively. Methods Recording the observation indicaters of 15 rabbits＇endo-epieardium MAP, around arrhythmia cause by myocardium ischemia, and compare them. Results The difference of the endo-epicardium oscillation amplitude APD90 does not have statistics significance, around the arrhythmia（P 〉 0.05）; But the APD50 difference has statistics significance（P 〈 0.05 ）, the own comparison of epicardium APD50 around arrhythmia has statistics significance（P 〈 0.05 ）. Conelusion Establishing synchronously recording non-damage endo-epicardium cardiac muscle MAP model successfully can find a good experiment platform to discuss arrhythmogenic mechanism.

关 键 词：无损伤 心内外膜 MAP 

分 类 号：R540.4[医药卫生—心血管疾病]