当归颗粒对抗氯化钙引起实验性心律失常的作用  

Effect of Dang Gui Ke Li on experimental arrhythmia induced by calcium chloride

作　　者：尹克春 刘淑娟 陈力 周文斌 牛平平 杨敏 

机构地区：[1]广州中医药大学第二附属医院心脏三科,广州510120

出　　处：《广东医学》2008年第11期1785-1786,共2页Guangdong Medical Journal

基　　金：广东省科技计划项目(编号:2004B33001008)

摘　　要：目的研究当归颗粒对抗氯化钙引起的实验性大鼠心律失常的作用。方法采用氯化钙诱导的大鼠心律失常模型,观察当归颗粒对抗实验性心律失常的预防保护作用。结果灌胃当归颗粒(1.35,2.70,5.40g/kg)可剂量依赖的降低氯化钙诱发的大鼠心律失常的死亡率,同时可减少心律失常发生率、延迟心律失常出现的时间并缩短心律失常的持续时间。结论当归颗粒对氯化钙诱导的实验性大鼠心律失常有较好的预防保护作用。Objective To investigate the effect of Dang Gui Ke Li （DGKL） on experimental arrhythmia induced by calcium chloride （CaCl2 ）. Methods Arrhythmie models induced by CaCl2 in rats were used to study the effect of DGKL on experimental arrhythmia. Results DGKL （ 1.35, 2.70, 5.40 g/kg） decreased the incidence and mortality of arrhythmia, delayed the emergence time and shorted the duration of arrhythmia in rats induced by CaCl2 in a concentration - dependent manner. Conclusion DGKL has a significantly protective and preventive effect on experimental arrhythmia induced by CaCl2 in rats.

关 键 词：当归颗粒 抗心律失常 氯化钙 大鼠 

分 类 号：R285.5[医药卫生—中药学] R541.7[医药卫生—中医学]