风湿性心脏病患者血浆脑钠素水平变化及意义  

Variation and Its Clinical Significance of Plasma BNP in Patients of Rheumatic Heart Disease

作　　者：陈永生[1] 方伟[1] 

机构地区：[1]郑州大学第五附属医院心内科,郑州市450052

出　　处：《医药论坛杂志》2008年第20期12-13,15,共3页Journal of Medical Forum

摘　　要：目的探讨风湿性心脏病(风心病)患者血浆脑钠素(BNP)水平与其心功能及左心室射血分数(LVEF)间的关系。方法采用酶联免疫法检测60例风心病患者及20例正常人血浆BNP含量并和心脏彩色多普勒超声诊断仪测量LVEF进行比较。结果风心病患者血浆BNP含量明显高于正常对照组(P<0.01),与NYHA心功能分级程度呈正相关(r=0.71,P<0.05),并与LVEF呈负相关(r=-0.52,P<0.05),与单纯瓣膜病变和联合瓣膜病变无统计学意义(P>0.05)。结论血浆BNP水平随风湿性心脏病心功能严重程度加重而升高,对于评价风心病心功能有重要临床意义。Objective To investigate the correlation between the blood plasma brain natri- uretic peptide （BNP） levels and heart function as well as left ventricular ejection function in patients with rheumatic heart disease （RHD）. Methods Total 60 patients with RHD and 20 healthy subjects were investigated by measuring the blood plasma BNP levels by immumofluorescence method and LVEF by color Doppler echocardiography. Results The blood plasma BNP levels in patients with RHD were markedly higher than those of control subjects （ P 〈 0.01 ） ,and the increase of the blood plasma BNP levels was significantly correlated with the severity of NYHA functional class （ r = 0. 71, P 〈 0. 05 ） and were negatively correlated with the LVEF （ r = - 0. 52, P 〈 0. 05 ）. There was not statistically significant among the blood plasma BNP levels of different valve disease （ P 〉 0. 05 ）. Conclusion The increase of the blood plasma BNP levels in patients with RHD is closely correlated with the severity of HF, which is significant for diagnosing heart function of RHD.

关 键 词：风湿性心脏病 脑钠素 心功能 心力衰竭 左室射血分数 

分 类 号：R541.2[医药卫生—心血管疾病]