氨磷汀预防顺铂所致肾毒性  

Amifostine Pretreatment for Protection Angainst Cisplatin-induced Nephrotoxicity

作　　者：胡全[1] 张丽慧[1] 耿宝琴[2] 许敬尧[3] 

机构地区：[1]杭州师范大学基础医学部药理学教研室,杭州310018 [2]浙江大学医学院药理学教研室,杭州310058 [3]浙江大学医学院病理学教研室,杭州310058

出　　处：《中国现代应用药学》2008年第5期382-386,共5页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的观察氨磷汀对顺铂所致肾毒性的预防性保护作用。方法随机将大鼠分成5组,即空白对照组,顺铂5mg·kg-1组,顺铂7.5mg·kg-1组,顺铂5mg·kg-1+氨磷汀200mg·kg-1组和顺铂7.5mg·kg-1+氨磷汀200mg·kg-1组,分别测定肾脏脏器系数、血尿素氮、肌酐水平,并做肾组织病理学检查。结果顺铂5mg·kg-1及7.5mg·kg-1组大鼠BUN、Cr值均明显高于对照组和加用氨磷汀组,差异有显著性(P<0.05或P<0.01);氨磷汀组肾脏脏器系数明显下降,病理分级显示氨磷汀肾损害保护率分别为61.5%和56.8%。结论氨磷汀能有效地预防顺铂所致肾毒性。OBJECTIVE Amifostine, a cytoprotector of broad-spectrum, protects normal tissues from the toxic effects of certain anticancer drugs. This study aims to observe the protective effect of amifostine angainst cisplatin-induced nephrotoxicity. METHODS Thirty-five Sprague-Dawley rats were randomly divided into 5 groups： control group（0.9% saline solution）, cisplatin 5 mg·kg^-1 group, cisplatin 7.5 mg·kg^-1 group, cisplatin 5 mg·kg^-1 ＋ amifostine 200 mg·kg^-1 group and cisplatin 7.5 mg·kg^-1 ＋ amifostine 200 mg·kg^-1 group. Organ coefficient of kidneies, serum BUN, creatinine were measured. Renal histopathological lesions were examined by light microscopy. RESULTS Compared with control group and cisplatin 5 mg·kg^-1 ＋ amifostine 200 mg·kg^-1 or cisplatin 7.5 mg·kg^-1 ＋ amifostine 200 mg·kg^-1 group, serum BUN and creatinine were significantly elevated in cisplatin 5 mg·kg^-1 and cisplatin 7.5 mg·kg^-1 groups （ P 〈 0.05 or P 〈 0.01 ）. The organ coefficients of kidneies with amifostine were decreased obviously. The rate of nephroprotection in pathological grade was 61.5% and 56.8%, respectively. CONCLUSION Amifostine is able to protect the nephrotoxicity induced by cisplatin.

关 键 词：氨磷汀 顺铂 肾毒性 化疗 

分 类 号：R965.3[医药卫生—药理学] R979.1[医药卫生—药学]