帕罗西汀联合心理疗法治疗脑卒中后抑郁临床疗效观察  

The Effect of Paroxetine Plus Psychotherapy in the Treatment of Post-stroke Depression

作　　者：万继峰[1,2] 徐云燕[2] 任歆[2] 徐涛[2] 郝丽梅[2] 付国庆[2] 

机构地区：[1]中国科学院心理所,北京100101 [2]北京煤炭总医院神经内科,北京100028

出　　处：《中国现代应用药学》2008年第5期467-470,共4页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的探讨帕罗西汀(乐友)联合心理疗法治疗脑卒中后抑郁的疗效。方法将106例患有脑卒中后抑郁患者随机分成2组,帕罗西汀组58例给予口服帕罗西汀20mg.d-1,帕罗西汀联合心理治疗组48例,在口服帕罗西汀20mg.d-1基础上,同时给予心理治疗,2次/周,每次40～60min。共8周;所有患者在治疗前、治疗2周末、4周末、6周末、8周末,分别采用HAMD量表和临床卒中残疾量表(Barthel指数)进行评分测定。结果治疗8周后,联合治疗组HAMD评明显低于帕罗西汀组,BI评分明显高于帕罗西汀组(P<0.01)。结论帕罗西汀联合心理疗法治疗脑卒中后抑郁疗效较好。OBJECTIVE To study the effect of paroxetine plus psychotherapy in the treatment of post-stroke depression. METHODS 106 patients with post-stroke depression were randomly divided into treatment group and control group, the treatment group were given paroxetine plus psychotherapy, the control group were given paroxetine only for 8 weeks. The efficacy was assessed by Hamaihon Depression Rating Scale（HAMD） and Barthel Index （BI）. RESULTS The score of HAMD of the treatment group was significantly lower ＇after 8 weeks than that of the control group,and the score of BI of the treatment group was significantly higher after 8 weeks than that of the control group （P 〈 0.01 ）. CONCLUSION Paroxetine plus psychotherapy has better effect in treatment of post-stroke depression.

关 键 词：脑卒中后抑郁 帕罗西汀 心理治疗 

分 类 号：R289.6[医药卫生—方剂学] R971.43[医药卫生—中药学]