咪达唑仑持续静脉推注治疗小儿难治性惊厥的疗效观察  

The Rapeutc Effects of Midazolam on Refractoriness Convulsion in Children

作　　者：王从军[1] 肖成云[1] 王晋妮[2] 

机构地区：[1]荆楚理工学院医学院,湖北荆门448000 [2]荆门市第一人民医院儿科,湖北荆门448000

出　　处：《荆门职业技术学院学报》2008年第9期53-54,共2页Journal of Jingmen Technical College

摘　　要：目的:观察咪达唑仑持续静脉推注治疗小儿难治性惊厥的临床疗效及不良反应。方法:选择以频繁惊厥为主要表现且按传统方法抗惊厥治疗无效的住院儿童42例。研究分两组,对照组21例在出现频繁惊厥采用苯巴比妥联用安定治疗无效后以安定加入葡萄糖溶液静脉持续滴注,研究组则给予咪达唑仑静脉持续推注。对比两组疗效,同时观察两组的不良反应。结果:研究组21例患儿有20例惊厥完全得到控制,1例无效,有效率为95.2%,且气道分泌物少,无明显呼吸抑制及其他不良反应。对照组仅12例惊厥被完全控制,9例无效,有效率为57.1%,且部分患儿在治疗过程中出现呼吸抑制,气道分泌物增加等不良反应。两组有效率具显著性差异(P<0.01)。结论:咪达唑仑对小儿难治性惊厥疗效明显,不良反应少,可作为治疗小儿难治性惊厥的首选方法。Objective：To observe the therapeutic effects and adverse reactions of midazolam on refractoriness convulsion by continuous intravenous drip. Methods ：42 cases with refractoriness convulsion were divided into two groups. Valium were given by continuous intravenous drip in 21 cases in control group and midazolam were given in the other 21 cases in treatment group and adverse effects were obsered in two groups. Results：The convulsion in 20 cases were controled in treatment group and the efficienency is 95.2%. The convulsion in 12 cases were healed in control group and the efficienency is 57.1%. There is a significant difference between two groups （ P 〈 0.01 ）. Furthermore ,the advrse effects in treatment group is less than in control group. Conclusion：Midazolam is the first way in treating the refractoriness convulsion in children by continuous intravenous drip.

关 键 词：儿童 惊厥 咪达唑仑 

分 类 号：R720.597[医药卫生—急诊医学]