NIR技术在丹酚酸B提取在才质量监控中的应用  

Application of On-Line Quality Control for Salvianolic Acid B by NIRS

作　　者：刘岩[1] 张延莹[1] 张金巍[1] 

机构地区：[1]天津天士力现代中药资源有限公司,中国300410

出　　处：《华夏医药》2008年第5期359-363,共5页Hua-xia Medicine

摘　　要：目的利用NIR技术研究并建立丹酚酸B的含量检测模型，实现产业化规模丹酚酸B提取过程的在绝质量监控。方法在绝采集近红外光谱，同时进行丹酚酸B的HPLC检测，采用偏最小二乘法建立提取过程的丹酚酸B含量检测模型。结果提取模型的最佳建模波段为9815-5430cm^-1，模型相关系数R=0.9784，校正均方差RMSEC=0．258。预测值与真实值的平均相对误差〈5％。结论利用NIR技术能够实现丹酚酸B提取过程的在缀质量监控。Objectives To research and develop models of the salvianolic acid B＇s content by NIR spectroscopy, realized on-line quality control of extracting process of herbal medicine system in product scale. Methods On-line NIR detection of extracting process to obtain the NIR spectrum and HPLC detection was carried out to determine the content of salvianolic acid B. PLS method was used to establish the relationship between the information of NIR and HPLC. Results For extracting model： the optimum NIR wavelength range was 9815-5430cm^-1 , R=0.9784, RMSEC=0.258. The average relative error was 〈5%. Conclusion NIR technique can be used in the on-line quality control of the salvianolic acid B＇s production.

关 键 词：近红外 高效液相色谱法 丹酚酸B 在线质量监控 生产规模 

分 类 号：R927.11[医药卫生—药学]