感染性疾病患儿血清维生素A水平及影响因素分析  

A study on vitamin A level among children with pneumonia and diarrhea and its risk factors

作　　者：孙吉萍[1] 赵惠欣[1] 方鹤松[1] 

机构地区：[1]首都儿科研究所附属儿童医院内科,北京100020

出　　处：《北京医学》2008年第11期654-656,共3页Beijing Medical Journal

摘　　要：目的探讨肺炎、腹泻患儿血清维生素A状况及其影响因素。方法采用微量荧光法测定60例肺炎、85例腹泻患儿和100例健康儿童血清维生素A值,进行多元回归分析。结果肺炎、腹泻患儿的血清维生素A值分别为(1.0±0.4)μmol/L、(0.7±0.4)μmol/L,均明显低于健康儿童的(1.9±0.6)μmol/L(P﹤0.01)。两组亚健康维生素A缺乏(SVAD)发病率分别为28.3%、54.1%,均明显高于健康儿童的1.0%(P﹤0.005)。多因素分析表明,肺炎组血清维生素A低的危险因素为发热、病情重、家居农村,腹泻组血清维生素A低的危险因素为年龄小、高热、脱水、日大便次数多。结论肺炎、腹泻患儿血清维生素A水平低于健康儿童。年龄小、农村患儿、发热和脱水与体内维生素A状况关系较密切。Objective To explore the serum vitamin A（Vit A）level among children with pneumonia or diarrhea and its risk factors. Methods The detection of serum vitamin A level and regression analysis were performed in 60 children with pneumonia, 85 children with diarrhea and 100 health children. Serum Vit A 〈 0.70μmol/L was considered as subclinical vitamin A deficiency （SVAD）. Results Serum Vit A levels of the cases with pneumonia, diarrhea and health children were（1.0±0.4）μmol/L, （0.7±0.4）μmol/L and（1.9±0.6）μmol/L, respectively（F=152.890, P 〈 0.01）. The incidences of SVAD in three groups were 28.3%, 54.1% and 1.0%, respectively （X^2=67.381, P 〈 0.005）. The risk factors included rural residence, fever and severity of the condition in pneumonia group. Young age, high fever, dehydration and more stool motions were risk factors in the diarrhea group. Conclusions The serum Vit A level among children with pneumonia and diarrhea is lower than that in health children. The significant factors for development into lower serum Vit A level include young age, serious symptoms such as fever, dehydration, more stool motions and rural residence.

关 键 词：肺炎 腹泻 亚临床维生素A缺乏 

分 类 号：R725.1[医药卫生—儿科] R446.1[医药卫生—临床医学]