IL-6强化的肠外营养对肝硬化大鼠肝切除术后残肝的影响  

Effects of parenteral nutrition with interleukin-6 on remnant liver after hepatectomy in cirrhotic rats

作　　者：陈伟[1] 曹杰[1] 罗建威[1] 罗时敏[1] 杨平[1] 

机构地区：[1]广州医学院附属广州市第一人民医院普通外科,510180

出　　处：《中华肝胆外科杂志》2008年第10期735-738,共4页Chinese Journal of Hepatobiliary Surgery

基　　金：广州市科技攻关计划项目（200523-E0181）

摘　　要：目的探讨自细胞介素-6（IL-6）强化的肠外营养（PN）对肝硬化大鼠肝切除术后残肝的影响。方法6只正常大鼠为正常对照组（A组），24只肝硬化大鼠随机分为4组（B～E组，n=6）：B组：肝硬化术前组，C组：肝切除＋颈内静脉插管术后1d组，D组：肝切除术后行PN5d组，E组：肝切除术后行PN＋IL-6 5d组。测大鼠肝功能，炎症反应和脂质过氧化指标，肝组织ALBmRNA的表达。结果与D组比较，E组血清AST、ALT、ALP显著下降（P〈0．05），血清ALB显著升高（P〈0．05）；血清IFN-γ、TNF—α、MDA显著下降（P〈0．05），血清SOD活性显著升高（P〈0．05）；肝组织ALB mRNA表达显著升高（P〈0．05）。结论PN＋IL-6可以加快肝硬化大鼠肝切除术后肝功能的恢复，减轻炎症反应和脂质过氧化损伤，促进肝脏蛋白合成。Objective To explore the effects of parenteral nutrition （PN） enhanced with inter leukin-6 （IL-6） on remnant liver after hepatectomy in cirrhotic rats. Methods Six normal rats severed as normal group, 24 rats with liver cirrhosis were randomly divided into pre-operation group （n=6）, posthepatectomy with jugular vein catheter 1 day group （n=6）, post operation PN 5 day group （n= 6）, post-operation PN＋IL-6 5 day group （n=6）. Liver function, inflammatory responses and lipid peroxidation and expression of ALB mRNA in the liver tissue were detected. Results Compared with the PN 5 day group, serum AST, ALT and ALP were lower（P〈0.05）, serum ALB higher（P〈 0.05）, serum IFN-γ, TNF-α and MDA content lower（P〈0.05）, serum SOD activity higher r（P〈 0.05）, expression of ALB mRNA in the liver tissue higher（P〈0. 05） in the PN＋IL-6 5 day group. Conclusion Posthepatectomy parenteral nutrition enhanced with IL-6 in cirrhotic rats can speed up liver function recovery, reduce inflammatory responses and lipid peroxidation damage and promote liver protein synthesis.

关 键 词：肝硬化 肝切除术 肠外营养 白细胞介素-6 

分 类 号：R686[医药卫生—骨科学]