NOD/SCID小鼠模型在实验血液学研究中的应用  

Application of NOD/SCID Mouse Model in Experimental Hematology Research

作　　者：于文俊[1] 杨文华[2] 史哲新[2] 杨向东[2] 王慧娟[1] 

机构地区：[1]天津中医药大学,天津300193 [2]天津中医药大学第一附属医院血液科,天津300193

出　　处：《中国实验动物学报》2008年第5期391-395,共5页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然科学基金资助(编号:30672743);天津市应用基础研究项目(07JCYBJC11500)

摘　　要：NOD/SCID(非肥胖糖尿病/重症联合免疫缺陷)小鼠是在SCID(重症联合免疫缺陷)小鼠的基础上与非肥胖性糖尿病小鼠(NOD/Lt)品系回交的免疫缺陷鼠。NOD/SCID小鼠既有先天免疫缺陷,又有T和B淋巴细胞缺乏,各种肿瘤细胞可以植入,且较少发生排斥反应及移植物抗宿主病(GVHD),所以NOD/SCID小鼠逐渐成为血液学实验研究的有用工具。本文从NOD/SCID小鼠的生物学特性、建立人类白血病模型、干细胞移植、药物研究及NOD/SCID小鼠应用中存在的不足和改良等方面综合述评。NOD/SCID （non-obese diabetic/severe combined immunodeficient） mice are immunodeficient mice which are generated by backcrossing severe combined immunodeficient mice with non-obese diabetic mice strains. NOD/SCID mice are both innate immunodeficient and lack of T and B lymphocytes. Various tumor cells can be implanted in those mice with few occurrence of rejection and graft-versus-host disease （GVHD）. Therefore, NOD/SCID mice gradually become a useful tool in studies of experimental hematology. This paper is a comprehensive review of the biological characteristics of NOD/SCID mice, and their application in the establishment of human leukemia model, research on stem cell transplantation, drug research, and the drawbacks and improvement of application of NOD/SCID mice.

关 键 词：NOD/SCID小鼠 实验血液学 动物模型 

分 类 号：R652[医药卫生—外科学]