植物雌激素对女性健康的影响  

Effects of phytoestrogens on women's health

作　　者：陆晓和[1] 金念祖[2] 

机构地区：[1]南京军区南京总医院药学部,江苏南京210002 [2]南京医科大学公共卫生学院,江苏南京210029

出　　处：《医学研究生学报》2008年第10期1086-1090,共5页Journal of Medical Postgraduates

基　　金：国家自然科学基金资助项目(批准号:30572133)

摘　　要：植物雌激素是指一大类在结构和功能上与雌二醇相似的源自植物的天然化合物,它们能与体内的雌激素受体选择性结合,并模仿雌激素的作用。早期的流行病学研究发现,亚洲女性乳腺癌的发病率低与其摄入富含植物雌激素的膳食有关,由此引发了人们对植物雌激素的广泛关注。许多研究结果表明,植物雌激素可预防更年期女性的心血管疾病,减轻更年期的骨质疏松症和其他症状,但也有一些研究结果并未观察到这些作用。植物雌激素对女性乳腺癌预防作用的报道也不一致,但在少年和青春期较多地摄入富含植物雌激素的膳食可降低成年期患乳腺癌的风险。鉴于植物雌激素对女性健康作用的研究结果尚不确定,故不推荐更年期女性服用含异黄酮或其他植物雌激素的制剂。Phytoestrogens are a group of plant-derived substances that are structurally or functionally similar to mammalian estradiol.It can selectively bind to the estrogen receptor,mimicking the effects of estrogen.Interest in phytoestrogens has been fueled by early epidemiologic studies that suggested low incidence of breast cancer in Asian countries with high soy intake.In addition to its potential role in preventing breast cancer,there has been much interest in using phytoestrogens for the menopause related symptoms in postmenopausal women.Many researchers have found that phytoestrogens can protect the cardiovascular system and reduce menopausal symptoms such as osteoporosis and hot flash when applied during early postmenopause,but others have failed to get similar results.Data disagree on the role of phytoestrogens in breast cancer prevention but suggest that exposure to phytoestrogens in childhood or early adolescence may reduce the risk of the problem.Considering the controversy concerning the benefit of phytoestrogens to women＇s health,patients with climacteric complaints or the fear of developing osteoporosis should not be advised to take preparations containing phytoestrogens.

关 键 词：植物雌激素 乳腺癌 骨质疏松症 心血管疾病 更年期症状 

分 类 号：R392.6[医药卫生—免疫学]