TIG2在寻常型银屑病中的表达变化及意义  

Alteration of tazarotene induced gene-2 expression in psoriasis vulgaris

作　　者：郑焱[1] 罗素菊[1] 曾维惠[1] 彭振辉[1] 谭升顺[1] 郗彦萍[1] 

机构地区：[1]西安交通大学第二医院皮肤科,陕西西安710004

出　　处：《南方医科大学学报》2008年第10期1792-1794,共3页Journal of Southern Medical University

基　　金：国家自然科学基金(30400387);陕西省自然科学基金(2004C211)

摘　　要：目的研究TIG2在寻常型银屑病中的作用机制。方法用免疫组化和原位杂交的方法检测正常组织,未受累组织和银屑病皮损中TIG2蛋白和mRNA的表达变化。结果在正常组织及未受累组织中,TIG2表达于表皮全层,在银屑病周围皮损中,可见TIG2阳性染色于棘层上部,在棘层下部及基底层中表达较少,而在银屑病中间皮损中无表达。TIG2在正常和未受累皮肤基底层中的表达高于其在银屑病边缘皮损基底层中的表达(P<0.01);TIG2在正常皮肤和未受累皮肤中的表达高于其在银屑病中间皮损中的表达(P<0.01);银屑病边缘皮损基底上层中的表达高于其在银屑病中间皮损中的表达(P<0.01)。结论TIG2可保持表皮正常分化功能,TIG2的降低可能参与银屑病的发生和发展。Objective To investigate the role oftazarotene induced gene-2 （TIG2） in psoriasis vulgaris. Methods TIG2 protein and mRNA expressions in normal tissues, psoriatic lesions and uninvolved skin tissues were detected by immunohistochemistry and in situ hybridization, respectively. Results TIG2 protein and mRNA were expressed in all the layers of normal and uninvolved epidermis. TIG2 expression was detected in the upper layers of the stratum spinosum of the marginal region of the psoriatic lesions, but not in the central area of the lesions. TIG2 expression was significantly lower in the basal layers of the central area of the paoriasis than that in the normal skin and uninvolved tissues （P〈0.01）, and also lower in the marginal regions of the lesions （P〈0.01）.The suprabasal layers of the marginal region in the lesion showed significantly lower TIG2 expression than the central area of the lesion （P〈0.01）. Conclusion TIG2 may maintain the normal differentiation of epidermal keratinocytes and implicate in the pathogenesis and development of psoriasis vulgaris.

关 键 词：银屑病 TIG2 tazatotene 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]