不同剂量辛伐他汀治疗对不稳定性心绞痛患者早期血脂及C反应蛋白的影响  

The Effects of Simvastatin on Blood Lipids and Hypersensitive C Reactive Protein Levels in Early Stage of Unstable Angina

作　　者：郭纪群[1] 陆洋[1] 鄂小青 王秀娟[1] 

机构地区：[1]江苏省扬中市人民医院,江苏扬中212200

出　　处：《中国临床医学》2008年第5期597-598,共2页Chinese Journal of Clinical Medicine

基　　金：江苏省镇江市科技局2005年科学发展基金重点资助(FZ2005017)

摘　　要：目的:探讨不同剂量辛伐他汀对不稳定性心绞痛(UA)患者早期血脂和高敏C反应蛋白(hs-CRP)的影响。方法:本研究入选124例UA患者,分为两组:辛伐他汀A组73例,在常规治疗基础上加用辛伐他汀20mg·d-1;辛伐他汀B组51例,在常规治疗基础上加用辛伐他汀40mg·d-1,两组均于入院第2天及1周后抽血测定总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C),脂蛋白(a)[LP(a)]及高敏C反应蛋白(hs-CRP)水平。结果:辛伐他汀A组和辛伐他汀B组治疗1周后检测TC,LDL-C水平较治疗前明显下降(P<0.01),且B组TG下降显著(P<0.05)。辛伐他汀B组治疗1周后hs-CRP水平较治疗前有下降,但不具有统计学差异(P>0.05)。结论:辛伐他汀对不稳定性心绞痛患者早期即具有调脂作用,但未显示有抗炎作用。Objective：To investigate the effects of simvastatin on blood lipids and hypersensitive reactive protein levels in early stage of unstable angina（UA）. Methods：One hundred and twenty-two patients with unstable angina were divided into two groups： 20 mg simvastatin group （n = 73） and 40 mg simvastatin group （n = 51 ）, all patients were treated for a week. Serum lipids and hypersensitive C- reactive protein （hs-CRP） levels were measured before and after a week＇s intervention. Results： Application of simvastatin in early stage of UA significantly reduced levels of total cholestrol （TC） and low density lipoprotein cholestrol （LDL-C）（P〈0.01）, and the reduction of triglycerides （TG） was significant in 40 mg simvastatin group（P〈0. 05）. The reduction of serum levels of hs-CRP was observed in 40 mg simvastatin group, but the degree of reduction had no significant difference（P〉0.05）. Conclusion： Application of simvastatin in early period of UA can reduce levels of TC and LDL-C, but fails to show the anti-inflammatory activity.

关 键 词：辛伐他汀 心绞痛 不稳定性 C反应蛋白质 

分 类 号：R541[医药卫生—心血管疾病]