布地奈德吸入治疗可逆性气道高反应性疾病  

Clinical Research of Inhaling Budesonide on Treating Reversible Airway Hyperresponsiveness Disease

作　　者：唐颖[1] 许力军[1] 王学军[2] 秦桂香[1] 熊桂兰[1] 孙安凤[1] 李晓丹[1] 

机构地区：[1]吉林大学第一医院呼吸内科,吉林长春130021 [2]吉林大学第一医院检验科,吉林长春130021

出　　处：《中国临床医学》2008年第5期625-626,共2页Chinese Journal of Clinical Medicine

摘　　要：目的:探讨吸入布地奈德治疗可逆性气道高反应性疾病的作用。方法:64例中度支气管哮喘急性发作期患者,随机分为对照组32例和治疗组各32例。对照组用抗生素、茶碱常规治疗;治疗组在此基础上加用布地奈德雾化吸入。检测治疗前后患者肺功能、淋巴细胞亚群、IL-3及嗜酸性粒细胞计数的变化。结果:治疗组在改善肺功能、纠正淋巴细胞亚群功能失调、降低嗜酸性粒细胞计数和IL-3水平方面明显优于对照组(P<0.05)。结论:吸入性布地奈德可以调节免疫失调,减轻气道炎症,降低气道高反应性,改善肺功能,值得临床推广应用。Objective：To approach the clinical effects on reversible airway hyperresponsiveness disease by inhaling budesonide. Methods： Sixty-four patients with midrange acute episode asthma were randomly divided into two groups, the control group（n = 32） and the treatment group（n = 32）. The control group were treated with antibiotics, aminofilina, while the treatment group were treated with antibiotics, aminofilina and budesonide. The pulmonary function, leukomonocyte subgroup,IL-3 and the eosinophils count were compared before and after the treatment. Results： The treatment group surpassed the control group obviously in amendmenting pulmonary function,retrieving leukomonocyte subgroup functional disorder, degrading eosinophils count and IL-3. Conclusion： Inhaling budesonide can accommodate immune disturbance, palliate airway inflammation,improve pulmonary function which should be recommended generally by clinic.

关 键 词：布地奈德 气道高反应 IL-3 肺功能 淋巴细胞亚群 

分 类 号：R562.2[医药卫生—呼吸系统]