氟康唑治疗复发性念珠菌阴道炎的临床研究  

Clinical experience of treating recurrent candidal vaginitis with fluconazole capsule（ diflucan capsule）

作　　者：薛建芳[1] 毕华[1] 倪亚华[1] 

机构地区：[1]湖州市中医院妇产科,浙江省湖州313000

出　　处：《中国基层医药》2008年第10期1638-1639,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的评价氟康唑的两种治疗方案治疗复发性念珠菌阴道炎的临床疗效。方法对照组（也称单次用药组）：夫妻双方同时顿服氟康唑胶囊150mg，同时特比萘芬阴道泡腾片塞阴道，1次／d、1片／次，连用7d为1个疗程；治疗组（也称连续用药组）：在1个疗程结束后，在治疗后的每月月经期的第1天夫妻双方同时顿服氟康唑胶囊150mg，月经干净后用特比萘芬阴道泡腾片塞阴道，1次／d、1片／次，连用7d，共3个月。评价两种治疗方案的远期、近期疗效及复发率。结果两种治疗方案治疗复发性念珠菌阴道炎近期疗效（1周）差异无统计学意义（P〉0．05），但连续用药组的远期疗效（3个月）明显好于单次用药组（P〈0．01），复发率也明显下降（P〈0．01）。结论治疗复发性念珠菌阴道炎，连续用药治疗3个月的方案是安全有效的，不良反应少。Objective To appraise two kinds of treatment plan of treating recurrent candidal vaginitis with fluconazole capsule. Methods The control group（ also called the single medication） ：husband and wife take fluconazole capsule 150mg and add terbinafine hydrochloride vaginal effervescent tablets into the vagina,one time a day and one tablet a time, taking 7 days continually is a treatment course; the treatment group （ also called taking drugs continuously） ：after a treatment course, at the first day of the menstrual period, husband and wife take fluconazole capsule 150mg at the same time, after the clean of menstruation, add terbinafine hydrochloride vaginal effervescent tablets into the vagina,one time a day and one tablet a time,taking 7 days continuously,three months in total. Appraise the two kinds of treatment plans from long-term, short-term curative effect and the recurrent rate. Results The curative effect of the two kinds of treatment plan about the treatment of recurrent candidal vaginitis ,there is no difference between the short-term（ one week） curative effect（ P 〉 0.05 ）, but the long-term curative effect in the group of taking tablets continuously is obviously better than the single medication（P 〈 0.01 ）, and the recurrent rate also obviously decreases（ P 〈 0.01 ）. Conclusion The treatment plan of taking the tablets continuously is the safey, effective treatment plan for the recurrent candidal vaginitis, no adverse reaction had been discovered.

关 键 词：念珠菌病 外阴阴道 抗菌药 氟康唑 特比萘芬 

分 类 号：R711[医药卫生—妇产科学]