阻塞性睡眠呼吸暂停综合征患者血清IL-6、TNF-α测定的临床意义  

Clinical Significance of Serum Levels of IL-6 and TNF-α in Patients with Obstructive Sleep Apnea Syndrome

作　　者：计明[1] 李从荣[1] 

机构地区：[1]武汉大学人民医院检验科,武汉430060

出　　处：《微循环学杂志》2008年第4期43-45,共3页Chinese Journal of Microcirculation

摘　　要：目的:探讨阻塞性睡眠呼吸暂停综合征(OSAS)患者血清IL-6、TNF-α水平测定的临床意义。方法:68例OSAS患者分为轻度组(36例)和中、重度组(32例),同时选取健康对照者30例,采用酶联免疫吸附法(ELISA)测定其血清IL-6、TNF-α水平,同时检测睡眠呼吸暂停低通气指数(AHI)及夜间最低血氧饱和度(SaO2),并进行相关性分析。32例中、重度OSAS患者经鼻持续正压通气(nCPAP)治疗,于治疗前及治疗后监测AHI、SaO2、IL-6和TNF-α水平。结果:OSAS患者AHI和血清IL-6、TNF-α水平显著高于对照组(P<0.01),平均SaO2和最低SaO2与对照组相比明显降低(P<0.01)。中、重度OSAS患者经nCPAP后AHI和最低SaO2明显改善,血清IL-6和TNF-α水平均较治疗前明显降低(P<0.01)。OSAS患者血清IL-6、TNF-α水平分别与AHI呈正相关(r=0.75,r=0.82,P<0.01);与SaO2呈负相关(r=-0.65、r=-0.74,P<0.01)。结论:血清IL-6、TNF-α参与了OSAS的发病,而且与病情严重程度密切相关。Objective:To investigate the change and clinical significance of serum levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in patients with obstructive sleep apnea syndrome(OSAS).Method:68 patients with OSAS(including 36 cases of mild OSAS and 32 cases of severe OSAS)and 30 normal volunteers were selected.32 cases with severe OSAS were received nasal continuous positive airway pressure(nCPAP)treatment and apnea hypopnea index(AHI),SaO2,serum IL-6 and TNF-α level were tested before and after treatment.Serum level of IL-6 and TNF-α were measured by ELISA.Furthermore,linear correlations were performed between these biochemical parameters and sleep-breathing parameters of patients with OSAS.Results:Serum level of IL-6,TNF-α and AHI were significantly higher in OSAS patients than those in control subjects(P<0.01).The levels of IL-6 and TNF-α and AHI of severe OSAS patients were obviously decreased after treatment,while SaO2 were significantly increased after treatment.The serum level of IL-6 and TNF-α were correlated positively with AHI and those were correlated negatively with the lowest SaO2(IL-6:r=0.75,r=-0.65,P<0.01;TNF-α:r=0.82,r=-0.74,P<0.01,respectively).Conclusion:IL-6 and TNF-α play an important role in OSAS and the serum levels of IL-6 and TNF-α are correlated with severity of OSAS.

关 键 词：阻塞性睡眠呼吸暂停综合征 血清IL-6 临床意义 TNF 睡眠障碍性疾病 测定 呼吸系统疾病 脂质代谢异常 

分 类 号：R766.43[医药卫生—耳鼻咽喉科] R581.1[医药卫生—临床医学]