氯诺昔康对手术致痛大鼠脊髓背角COX-2表达的影响  

Effects of Lornoxicam on Expression of Cyclooxygenase-2 in Dorsal Horn of Spinal Cord in Rat Incision Model

作　　者：翁险峰[1] 杨锡馨[2] 

机构地区：[1]福建医科大学附属协和医院麻醉科,福建福州350001 [2]福建医科大学附属第一医院麻醉科

出　　处：《中国误诊学杂志》2008年第35期8569-8571,共3页Chinese Journal of Misdiagnostics

摘　　要：目的:研究氯诺昔康对手术致痛大鼠脊髓背角COX-2表达的影响。方法:大鼠随机分为:对照组、模型组,三个氯诺昔康预处理模型组(制作手术致痛模型前20 min腹腔注射1、3、9 mg/kg)。3 h后,取出脊髓,采用免疫组化方法观察脊髓背角COX-2的表达。结果:模型组脊髓背角COX-2表达较强,而氯诺昔康可减少手术致痛引起的COX-2表达,并有量效关系。结论:氯诺昔康能对手术致痛引起脊髓背角COX-2的表达产生剂量依赖性的抑制作用。Objective：To investigate the effects of lornoxieam on COX-2 expression of spinal dorsal horn in the rat incision model. Method：Rats were randomly divided into five groups：control group,model group,three medicine groups which received lornoxicam （1、3、9 mg/kg） 20 min prior to the incision models. The expression of COX-2 were identified by immunohistochemical technique. Result ：The COX-2 expression in dorsal horn of spinal cord was significantly high in model group. Lornoxicam treatment markedly decreased the expression of COX-2 of dorsal horn in a dose-dependent manner. Conclusions：Pretrcatment with lornoxicam can produce the dose dependent inhibitory effect on COX-2 expression on spinal cord horn.

关 键 词：疼痛 手术后/药物疗法 吡罗昔康/药理学 环加氧酶抑制药/药理学 前列腺素内过氧化物合酶/代谢/药物作用 随机分配 大鼠 

分 类 号：R96[医药卫生—药理学]