N-{1-[取代吡啶(噻唑)甲基]-5-甲基-1H-1,2,3-三唑-4-甲酰基}-N′-(芳氧乙酰)肼的合成与生物活性  

Synthesis and Biological Activities of N-{1-[substituted pyridyl(thiazolyl)methyl]-5-methyl-1H-1,2,3triazol-4-formyl}-N′-(aryloxyacetyl) hydrazines

作　　者：严曼[1] 石德清[1] 王慧利[1] 

机构地区：[1]农药与化学生物学教育部重点实验室,华中师范大学化学学院,武汉430079

出　　处：《应用化学》2008年第11期1266-1270,共5页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金(20302002);教育部留学回国人员基金(2007[1108])资助项目

摘　　要：采用2-氯-5-(氯甲基)吡啶和2-氯-5-(氯甲基)噻唑为原料,经过叠氮化、乙酰乙酸乙酯环化、水解、酰氯化,然后与芳氧乙酰肼的缩合反应,合成了9种目标化合物,其结构经1H NMR、IR、MS和元素分析测试技术确证,初步的生物活性测定结果表明,目标化合物在100 mg/L质量浓度下显示出良好的除草活性,但杀虫活性较弱。In order to develop novel high activity and low toxicity agrochemicals, a series of title compounds were synthesized by the muti-step reaction with 2-chloro-5-（chloromethyl） pyridine and 2-chloro-5-（ chloro- methyl） thiazole as the starting materials, followed by the cyclization with ethyl acetoacetate, hydrolysis, halogenation and condensation with aryioxyacetyl hydrazines. Their structures were confirmed by IR, I H NMR, EI-MS and elemental analyses. Preliminary bioassays indicate that most of the target compounds possess good herbicidal activity, but do not display strong insecticidal activity.

关 键 词：吡啶 噻唑 三唑 双酰肼化合物 生物活性 

分 类 号：O626[理学—有机化学]