肉桂酰基硫脲衍生物的合成及杀菌活性  

Synthesis and Antibacterial Activity of Cinnamic Acyl Thiourea Derivatives

作　　者：吕献海[1,2] 张袖丽[1] 唐文明[2] 

机构地区：[1]安徽农业大学应用化学系,合肥230036 [2]贵州大学精细化工研究开发中心,教育部绿色农药与农业生物工程重点实验室,贵阳550025

出　　处：《应用化学》2008年第11期1286-1290,共5页Chinese Journal of Applied Chemistry

基　　金：国家重点基础研究计划(2003CB114404);安徽省科技厅重点科研基金(06023092c);安徽省教育厅青年教师基金(2007jq1054)资助项目

摘　　要：以植物源成分肉桂酸为前体,通过酰氯化和硫脲化,合成了11个未见报道的酰基硫脲衍生物。经核磁共振氢谱、碳谱、红外光谱分析和元素分析测试技术,确认了新化合物的结构。初步的生物活性测试结果表明,在250 mg/L时化合物3b对小麦赤霉病菌抑制率为53.5%,化合物3f对半夏枯萎病菌抑制率为54.0%。Eleven new thiourea derivatives were synthesized by acylchlorination and then thioureation of cinnamic acid. The structures of the new compounds were confirmed by 1H NMR, 13C NMR and IR spectra and elemental analysis. Preliminary results of biological activity test indicates that some of them have certain inhibitory activity against Gibberella zeae and Rhizoetonia solani. Compound 3b exhibited 53.5% inhibition of Gibberella zeae and compound 3f exhibited 54.0% inhibition of Rhizoetonia solani at 250 mg/L.

关 键 词：肉桂酸 酰基硫脲 相转移催化 合成 生物活性 

分 类 号：O621.2[理学—有机化学]