地尔硫卓对D860促大鼠胰岛β细胞分泌功能的影响  

The effect of diltiazem on D860-induced insulin release of rats

作　　者：刘长勤[1] 杨叔禹[1] 陈宇红[2] 顾卫琼[2] 李小英[2] 宁光[2] 

机构地区：[1]福建医科大学附属厦门第一医院内分泌科厦门市糖尿病研究所,福建厦门361003 [2]上海交通大学医学院附属瑞金医院内分泌代谢科上海市内分泌代谢病临床医学中心

出　　处：《中国医师杂志》2008年第10期1330-1332,共3页Journal of Chinese Physician

基　　金：福建省卫生厅医学创新课题资助项目（2007-CXB-10）

摘　　要：目的观察钙拮抗剂地尔硫卓对大鼠β细胞功能及对磺脲类药物D860降糖作用的影响。方法实验分为对照组、地尔硫卓组、D860组以及地尔硫卓＋D860组，利用静脉糖耐量实验技术（IVGTT），观察地尔硫卓对正常大鼠胰岛素分泌的作用及其对磺脲类药物D860促胰岛素释放的影响，并对同组大鼠进行4周的慢性实验，观察长期给予地尔硫卓对大鼠胰岛功能扣D860降糖作用的影响。结果离体胰岛和急性动物实验表明，地尔硫卓可以抑制胰岛素的释放，从而减弱D860的降糖作用，但长期应用（4周）未产生相同的作用。结论地尔硫卓长期应用对大鼠胰岛功能及磺脲类药物的降糖作用无明显影响。Objective To investigate the effect of dihiazem, one of calcium antagonists, on the function of rat beta cells and the release of insulin induced by D860. Methods Intravenous glucose tolerance test （IVGTF） was conducted to assess beta-cell function of rats among control, dihiazem, D860, and diltiazem plus D860 groups, followed by treatment with diltiazem and D860 for 4 weeks respectively. Another IVG37F was carried out at the end of the study. Results The data showed that dihiazem could inhibit insulin released from normal SD rats. Moreover, it reduced the hypoglycemic effect promoted by D860. However, in long term, the rise of blood sugar in rats treated with D860 respectively was not found. Conclusion Dihiazem did not impair beta cells function and interfere the hypoglycemic effect of D860 in rats in long time.

关 键 词：地尔硫|ZHUO|/药理学 甲苯磺丁彬药理学 胰岛 

分 类 号：R587.1[医药卫生—内分泌]