肾移植受者血清可溶性白介素-2受体和超敏C反应蛋白变化研究  

Changes of soluble interleukin-2 receptor and high sensitivity C-reactive protein in renal ailograft recipients

作　　者：陈连周[1] 王东[2] 王长希[3] 曾文涛[1] 李雯[1] 汪谦[1] 

机构地区：[1]中山大学附属第一医院外科实验中心,广东广州510080 [2]中山大学附属第一医院检验科 [3]中山大学附属第一医院器官移植科

出　　处：《中国医师杂志》2008年第10期1346-1347,共2页Journal of Chinese Physician

摘　　要：目的探讨肾移植患者血清中可溶性白介素-2受体（sIL-2R）、超敏C反应蛋白（hs-CRP）表达水平的变化，了解其在移植排斥反应中的临床意义。方法测定91例肾移植患者血清及100名正常体检人员的血清中sIL-2R和hs-CRP浓度。使用乳胶增强免疫透射比浊检测hs—CRP，同时采用酶联免疫吸附法（ELISA）检测可溶性白介素-2受体（sIL-2R）的表达水平。结果急性排斥组sIL-2R和超敏C反应蛋白表达水平均显著高于肾功能稳定组及正常对照组，慢排组超敏c反应蛋白表达水平高于肾功能稳定组及正常对照组，肾功能稳定组可溶性白介素-2受体、hs—CRP的表达水平与正常对照组比较差异无统计学意义（P〉0．05）。结论监测sIL-2R和超敏C反应蛋白的表达水平有助于肾移植排斥反应的诊断。Objective To observe the changes of soluble interleukin-2 receptor（sIL-2R） and high sensitivity C-reactive （hs-CRP） protein in renal allograft recipients and its relationship with rejective response of renal allograft. Methods The concentration of sIL-2R and hs-CRP were detected in 91 patients with renal aliograft recipients and 100 health controls. CRP was measured by particle enhanced immuo- turbidimetric method, sIL-2R was detected by ELISA. Results The concentration of sIL-2R and hs-CRP in the recipients with acute rejection was significantly higher than those without graft rejection and health controls. The concentration of hs-CRP in the recipients with chronic rejection was higher than those without graft rejection and health controls. There was no evidence of significant changes in the concentration of sIL-2R and hs-CRP between the health control group and the recipients without graft rejection. Conclusion slL-2R and hs-CRP might play an important role in graft rejection. The measurement of sIL-2R and hs-CRP is important for the diagnosis of graft rejection.

关 键 词：肾移植 受体 白细胞介素2 C反应蛋白质 移植物排斥 

分 类 号：R699.2[医药卫生—泌尿科学]