紫外线减毒弓形虫对小鼠旋毛虫感染的影响  

Immunization with UV-Attenuated Toxopalsma gondii Influences Infection of Trichinella spiralis in Mouse Model

作　　者：朱佩娴[1] 郑焕钦[2] 王树萍[3] 张瑞琳[4] 黄世光[1] 吕芳丽[2] 

机构地区：[1]暨南大学医学院,广州510632 [2]中山大学中山医学院寄生虫学教研室,广州510080 [3]石河子大学医学院,石河子832002 [4]中山大学基础医学实验教学中心,广州510080

出　　处：《热带医学杂志》2008年第10期1038-1040,共3页Journal of Tropical Medicine

基　　金：广东省自然科学基金(No.06021302);教育部留学回国人员科研启动基金(教外司留[2006]331号);中山大学中山医学院留学回国人员启动基金(2005)

摘　　要：目的探讨紫外线减毒弓形虫免疫对小鼠旋毛虫感染的影响。方法ICR小鼠分为两组,实验组为紫外线减毒弓形虫免疫3周后再感染旋毛虫,对照组为旋毛虫单独感染。结果与旋毛虫单感染相比,小鼠预先经紫外线减毒弓形虫免疫再感染旋毛虫,在感染后5～14d其小肠内的成虫数明显增加(肠道排虫明显延迟),而感染后23～90d其肌肉中的幼虫数明显下降。结论紫外线减毒弓形虫免疫对小鼠旋毛虫感染具有一定的免疫调节和异源性保护作用。Objective To investigate the influence of UV-attenuated Toxoplasma gondii immunization on the infection of Trichinella spiralis in mouse models. Method Mice of experimental group were immunized with UVattenuated T. gondii, then infected with T. spiralis; mice infected with T. spiralis alone as control. Result Compared with control, there were significant higher adult worm burdens in the small intestine during 5-14 days post infection （delayed intestinal adult worm expulsion）, and lower muscular larval burdens during 23-90 days post infection, in mice immunized with UV-attenuated T. gondii. Conclusion Mice immunized with UV-attenuated T. gondii could change the course of T. spiralis infection, a significant heterologous protection from one parasite against the other.

关 键 词：旋毛虫 紫外线减毒弓形虫 免疫调节 

分 类 号：R383.15[医药卫生—医学寄生虫学]