2003-2006年湖北地区三级医院儿童感染大肠埃希菌耐药性分析  

Antibiotic Resistance Changing of Esherichia coli in Third Grade Hospitals of Hubei Province:A Dynamic Investigation

作　　者：夏维[1] 胡红兵[1] 康世秀[1] 熊宝华[1] 

机构地区：[1]武汉市儿童医院检验部,湖北武汉430016

出　　处：《中华医院感染学杂志》2008年第10期1471-1472,1484,共3页Chinese Journal of Nosocomiology

摘　　要：目的动态调查分析湖北地区儿童感染大肠埃希菌的耐药性变迁趋势,为临床合理使用抗菌药物提供科学依据。方法对湖北地区17所三级医院2003-2006年儿童患者各类临床标本,采用WHONET4-5软件对2901株大肠埃希菌的耐药率进行统计分析。结果4年中湖北地区儿童感染大肠埃希菌除对碳青酶烯类抗菌药物亚胺培南和美罗培南保持100%的敏感率外,对其他常用抗菌药物的耐药率多呈上升趋势,但儿童组大肠埃希菌耐药率低于成人组;对氨苄西林耐药率最高,达84%～90%;耐药率较低的抗菌药物有阿米卡星、头孢西丁、头孢他啶、头孢吡肟,为3%～25%。结论湖北地区儿童感染大肠埃希菌的耐药性呈上升趋势,应切实采取有效措施,合理使用抗菌药物,控制耐药菌的传播与流行。OBJECTIVE To investigate dynamically antibiotic resistance changing of Escherichia coli in Hubei province and provide the reference for clinical rational application of antibiotics. METHODS The WHONET4-5 software was used to analyze the antibiotic resistant rates of 2901 strains of E. coli isolated from all kinds of clinical specimen of children from 2003 to 2006 in the third grade hospitals of Hubei province. RESULTS Drugresistance rate of E. coli in children group was lower than that in adult group. Except for 100.0% susceptibility to carbopenems such as imipenem and Meropenem, in the four years, drug-resistance of the other antibiotics showed ascending tendency. Ampicillin showed the highest drug-resistance rate （84%- 90%）. The lower （3%- 25%） were amikaein, eefoxitin, eeftazidime, eefepime. CONCLUSIONS Antibiotic resistance of E. coli in children in Hubei province showed the ascending tendency. We should take effective rneasurement to control the spread and prevalence of the drug-resistant bacteria.

关 键 词：湖北地区 三级医院 儿童 大肠埃希菌 耐药性 

分 类 号：R378.21[医药卫生—病原生物学]