稀土2-氨基-4,6-二甲氧基嘧啶配合物的合成、表征及其生物活性  

Synthesis,characterization and biological activity of rare earth complexes with 2-amino-4,6-dimethoxypyrimidine

作　　者：许东芳[1] 沈智慧[1] 夏庆春[1] 杨自芳[1] 何其庄[1] 孙大志[1] 

机构地区：[1]上海师范大学生命与环境科学学院,上海200234

出　　处：《上海师范大学学报（自然科学版）》2008年第5期499-503,共5页Journal of Shanghai Normal University(Natural Sciences)

基　　金：国家自然科学基金项目(20671063);上海市科委纳米技术专项(0652nm046);上海师范大学一般科研项目(DKL829)

摘　　要：以稀土氯化物、2-氨基-4,6-二甲氧基嘧啶为原料,制备了一类新型稀土配合物,通过元素分析、红外光谱、紫外光谱等手段对其进行了表征,确定了该配合物的化学组成:RE2(ADP)(H2O)2Cl3(RE=La3+,Sm3+,Y3+,Er3+,ADP=2-氨基-4,6-二甲氧基嘧啶),抗菌实验结果表明:稀土配合物对大肠杆菌、金黄色葡萄球菌有较强的抑制作用,抗菌谱广.用MTT法对配合物使癌细胞凋亡能力做了初步研究,证明其具有使癌细胞凋亡的效果.Novel ternary complexes of rare earth ions （ RE ： La^3＋ , Sm^3 ＋ , y^3 ＋ , Er^3＋ ） with 2-amino-4,6-dlmethoxypyrimidine were synthesized. Basd on elemental analysis, FT - IR and UV - VIS, the compositions of these complexes were determined as Re2 （ADP） （H2O）2 Cl3. All these complexes exhibit antibacterial ability against Eseheriehia eoli, Staphylococcus aureus with a broad antimierobial spectrum. MTr was used to study the anticancer ability of the complexes, which demonstrated that the cancer cells were withered by these complexes.

关 键 词：配合物 抗菌 抗肿瘤 

分 类 号：O641.4[理学—物理化学] O614.33[理学—化学]