培哚普利对大鼠心肌缺血再灌注损伤的影响  

Effect of Perindopril on Myocardial Ischemia-Reperfusion Injury in Rats

作　　者：路映攀 牛凡[2] 郭文超[1] 

机构地区：[1]山西医科大学第一临床医学院心内科 [2]山西医科大学第一临床医学院

出　　处：《中西医结合心脑血管病杂志》2008年第11期1310-1311,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的观察培哚普利对大鼠心肌缺血再灌注损伤的影响。方法健康Wistar大鼠20只随机分成两组。培哚普利组结扎冠脉前20 min给予培哚普利2 mg/kg静脉注入;缺血再灌注组给予等量生理盐水静脉注入。测定血流动力学参数,左室收缩压(LVSP)、左室舒张末压(LVEDP)、左室内压最大上升速率(+dP/dTmax)及左室内压最大下降速率(-dP/dTmax),光镜观察心肌形态学改变。结果与缺血再灌注组比较,培哚普利组大鼠LVSP及±dP/dTmax均明显升高(P<0.05或P<0.01);缺血再灌注组大鼠心肌纤维断裂坏死,大量炎性细胞浸润,而培哚普利组无出血、坏死,有少量炎性细胞浸润。结论心肌缺血再灌注可导致缺血心肌进一步损伤,培哚普利可减少炎性细胞的浸润,对大鼠缺血再灌注损伤心肌有保护作用。Objective To study the effect of Perindopril on myocardial isehemia - reperfusion injury in rats. Methods Twenty healthy Wistar rats were randomly divided into perindopril group and myocardial isehemia- reperfusion （IR） group. The rat models of IR were established by ligating the left anterior descending coronary arteries （LADs） for 30 rain and then performing repefusion for i20 rain. The rats were infused with 2 mg/kg of perindopril into vein in perindopril group and equal quantity of normal sarine in IR group before ligating the LADs 20 rain. Left ventricular systolic pressure （LVSP）, left ventricular end - diastolic pressure （LVEDP）,left ventricular pressure maximal rate of rise and fall （＋dP/dT and -dP/dTmax） were measured. Morphology of myocardial tissue was observed with optics microscope. Results Compared with IR group, LVSP and ＋dP/dT in perindopril group were increased significantly （P〈0.05 or P〈0.01）. Myocardial fiber necrosis and inflammatory cell infiltration were found in IR group,but there was no necrosis and relatively little inflammatory cell infiltration in perindopril group. Conclusion Perindopril could prevent myocardial ischemia - reperfusion injury in rats by reducing inflammatory cell infiltration.

关 键 词：培哚普利 心肌缺血再灌注损伤 血流动力学参数 心肌/病理学 

分 类 号：R542.22[医药卫生—心血管疾病]