Th17细胞与自身免疫性疾病关系的研究进展  

Th17 lineage and autoimmune diseases

作　　者：张建宾[1] 

机构地区：[1]浙江大学免疫学研究所,杭州310058

出　　处：《国际免疫学杂志》2008年第6期411-415,共5页International Journal of Immunology

基　　金：国家自然科学基金资助项目（30471588）

摘　　要：CD4^＋辅助性T细胞（Th）通常可分为Th0、Th1、Th2和Th3等细胞亚群。Th1细胞过去一直被认为是介导迟发型超敏反应、引起组织损伤的主要细胞。近年来发现一群主要分泌白细胞介素-17（IL-17）、不同于Th1／Th2的新型CD4^＋T细胞亚群—Th17细胞。Th17细胞与自身免疫性疾病、肿瘤、炎性反应和移植排斥等的发生发展关系密切。CD4^＋ helper T （Th） cells were usually divided into Th0, Th1, Th2, and Th3 subsets over past several decades. Thl cells were long thought to mediate delayed type hypersensitivity and cause tissue damage. Recent studies have defined a previously unknown subset of the CD4 ^＋ T cells-the IL-17-producing T cells （Th17 lineage）that promises to change our understanding of immune regulation and immune pathogenesis. The roles of Th17 are being rapidly discovered and are providing insights into mechanisms of autoimmune diseases, tumor, inflammatory, graft rejection, etc. Thl7 lineage development and its important implications for autoimmune diseases were reviewed in this paper.

关 键 词：TH17细胞 TH1细胞 TH2细胞 自身免疫性疾病 

分 类 号：R593.2[医药卫生—内科学]