Numerical study of IP_3-induced Ca^(2+) spiral pattern evolution  

作　　者：唐军 马军 易鸣 贾亚 

机构地区：[1]College of Science, China University of Mining and Technology [2]Department of Physics and Institute of Biophysics, Huazhong Normal University [3]Department of Physics, Lanzhou University of Technology

出　　处：《Chinese Physics B》2008年第11期4100-4106,共7页中国物理B（英文版）

基　　金：Project supported by the National Natural Science Foundation of China (Grant Nos 10575041 and 10747005)

摘　　要：The effect of change in concentration of messenger molecule inositol 1,4,5-trisphosphate （IP3） on intracellular Ca^2＋spiral pattern evolution is studied numerically. The results indicate that when the IP3 concentration decreases from 0.27 μM, a physiologically reasonable value, to different values, the spiral centre drifts to the edge of the medium and disappears for a small enough IP3 concentration. The instability of spiral pattern can be understood in terms of excitability-change controlled by the IP3 concentration. On the other hand, when the IP3 concentration increases from 0.27 μM, a homogeneous area with a high Ca^2＋ concentration emerges and competes with the spiral pattern. A high enough IP3 concentration can lead the homogeneous area to occupy the whole medium. The instability of spiral pattern is ascribed to the change in stability of a stationary state with a high Ca^2＋ concentration.The effect of change in concentration of messenger molecule inositol 1,4,5-trisphosphate （IP3） on intracellular Ca^2＋spiral pattern evolution is studied numerically. The results indicate that when the IP3 concentration decreases from 0.27 μM, a physiologically reasonable value, to different values, the spiral centre drifts to the edge of the medium and disappears for a small enough IP3 concentration. The instability of spiral pattern can be understood in terms of excitability-change controlled by the IP3 concentration. On the other hand, when the IP3 concentration increases from 0.27 μM, a homogeneous area with a high Ca^2＋ concentration emerges and competes with the spiral pattern. A high enough IP3 concentration can lead the homogeneous area to occupy the whole medium. The instability of spiral pattern is ascribed to the change in stability of a stationary state with a high Ca^2＋ concentration.

关 键 词：spiral wave Ca^2＋ IP3 

分 类 号：N93[自然科学总论]