我院近5年临床分离克雷伯菌属的耐药变迁  

Antimicrobial Resistance Among Klebsiella .spp Isolated in 5 Consecutive Years in Our Hospital

作　　者：许建成[1] 周琪[1] 黄晶[1] 续薇[1] 

机构地区：[1]吉林大学第一医院,长春市130021

出　　处：《中国药房》2008年第32期2505-2507,共3页China Pharmacy

基　　金：吉林省卫生厅重点实验室科研课题(200640);吉林大学第一医院2006年青年基金项目

摘　　要：目的:了解近5年来我院临床分离克雷伯菌属的耐药变迁。方法:采用纸片扩散法进行药敏试验,根据美国临床实验室标准化研究所(CLSI)的标准判断结果;采用WHONET-5软件对耐药性数据进行分析。结果:2003～2007年我院收集克雷伯菌属840株,来自呼吸道标本、血液、分泌物者分别占59.3%、12.0%、10.1%。产超广谱β-内酰胺酶(ESBLs)克雷伯菌属检出率在51.0%～65.1%范围内。未发现对亚胺培南、美罗培南耐药的克雷伯菌属细菌,产ESBLs克雷伯菌属多重耐药严重,临床常用抗菌药物的耐药性呈逐年上升趋势。结论:应加强克雷伯菌属细菌耐药监测,了解其耐药变迁,指导临床合理用药,防止耐药菌株的传播。OBJECTIVE： To investigate the variance of antimicrobial resistance of Klebsiella.spp isolated in our hospital during the recent 5 years. METHODS： Disk diffusion test was used to study the antimicrobial resistance. The results were evaluated based on the criteria recommended by American Clinical and Laboratory Standards Institute. The data analysis was performed using WHONET-5 software. RESULTS： A total of 840 strains of Klebsiella.spp were collected from our hospital during 2003-2007, of which, 59.3% were from respiratory secretion specimen, 12.0% from blood specimen, and 10. 1% from secretions. The detection rate of ESBLs- producing Klebsiella.spp was from 51.0% to 65.1%. No Imipenem - and Meropenem- resistant Klebsiella.spp strain was detected. Susceptibility test showed that Klebsiella.spp- producing ESBLs was multiple resistant, and the antimicrobial resistance of Klebsiella.spp has increased year on year. CONCLUSION： Moni- toring of the drug resistance of Klebsiella.spp should be strengthened. The variation of the antimicrobial resistance of Kleb- siella.spp should be noted so as to direct rational drug use in the clinic and prevent spreading of drug resistant strains.

关 键 词：克雷伯菌属 Β-内酰胺酶类 抗药性 微生物 微生物敏感试验 药物监测 

分 类 号：R117[医药卫生—公共卫生与预防医学] R969.3