骨巨细胞瘤的动态增强MRI与^1H-MR波谱研究  

Study of DCE MRI and ^1H-MRS of giant cell tumor of bone

作　　者：过哲[1] 张晶[1] 梁伟[1] 李晓松[1] 张薇[1] 刘薇[1] 程晓光[1] 

机构地区：[1]北京大学第四临床医学院,北京积水潭医院放射科,北京100035

出　　处：《中国医学影像技术》2008年第10期1490-1492,共3页Chinese Journal of Medical Imaging Technology

基　　金：首都医学发展科研基金(2005-3033)

摘　　要：目的探讨骨巨细胞瘤的动态增强MRI及MR氢质子波谱的特点及其在骨巨细胞瘤诊断中的作用。方法采用3D fast SPGR序列对21例病理证实的骨巨细胞瘤进行动态增强扫描,并采用点分辨波谱序列（PRESS）对其中12例进行单体素MR氢质子波谱扫描,分别经过工作站处理,得到动态增强扫描时间-信号强度曲线（TIC）及MR氢质子波谱谱线。以手术病理为标准,对骨巨细胞瘤的动态增强扫描时间-信号强度曲线及MR氢质子波谱的特点进行分析。结果21例骨巨细胞瘤的TIC曲线中,19例为Ⅰ型曲线,2例为Ⅱ型曲线;12例MR氢质子波谱的谱线中,9例具有诊断价值,其中有2例出现明显的胆碱峰。结论骨巨细胞瘤的TIC曲线表现为速升下降型,^1H-MRS谱线缺乏胆碱峰或胆碱峰矮小。Objective To investigate the characteristic of dynamic contrast enhancement MRI scan and ^1 H-MR spectroscopy of giant cell tumor （GCT） of bone. Methods MRI was performed with 1.5T MR scanner. Twenty-one patients were examined with a three-dimensional fast SPGR dynamic MR imaging sequence. Singlevoxel ^1H-MR spectroscopy was performed in 12 of the 21 patients with point resolved spectroscopic sequence （PRESS）. The acquired images were post-processed, then time-intensity curves and ^1H-MR spectroscopic spectra of the GCT were obtained. Taking pathological diagnosis as gold standard, the types of time-intensity curves and ^1H-MR spectroscopic spectra were evaluated. Results Nineteen cases showed type Ⅰ curve; only 2 cases showed type Ⅱ curves. Nine of the 12 ^1 H-MR spectroscopy spectra had diagnostic value, and only 2 of them had noticeable choline peaks. Conclusion GCT shows type Ⅰ TIC curve, and has no noticeable or only have very small choline peak in ^1H-MR spectroscopy spectra.

关 键 词：骨肿瘤 磁共振成像 胆碱 

分 类 号：R445.2[医药卫生—影像医学与核医学] R738.1[医药卫生—诊断学]