急性心肌梗死发病季节和时间规律及其与树突状细胞功能的关系  

Circadian and seasonal variations in the incidence of acute myocardial infarction and their relation to functions of dendritic cells

作　　者：刘秀红[1] 杜亚军[1] 孙秀珍[1] 崔玉焕[1] 沈永照[1] 李霞[1] 苏宏正[1] 武华越[1] 王琴[1] 

机构地区：[1]枣阳市第一人民医院,湖北枣阳441200

出　　处：《临床心血管病杂志》2008年第9期659-661,共3页Journal of Clinical Cardiology

摘　　要：目的：了解急性心肌梗死（AMI）的季节性和日内时间性发病规律,探讨其与循环树突状细胞功能的关系。方法：收集272例AMI住院病例,对不同季节（分1～3月,4～6月,7～9月和10～12月4季）和日内时间段（分0∶01～6∶00,6∶01～12∶00,12∶01～18∶00、18∶01～24∶004个时段）的发病率进行比较和统计;检测血循环树突状细胞的功能。结果：AMI患者1～3月和10～12月发病率明显高于4～6月和7～9月,P〈0.01）。日内发病率以6∶01～12∶00明显高于其他时间段（P〈0.01）。患者和正常对照组循环树突状细胞的功能亦呈明显的季节和日内时间规律。AMI的季节和日内发病比例变化与树突状细胞的功能变化高度相关。结论：AMI的发病率有冬春季明显高于夏秋季、日内以6∶01～12∶00明显高于其他时间段的规律特征,树突状细胞介导的免疫炎症反应可能是这一规律的机制之一。Objective： To determine the circadian and seasonal variations in the incidence of acute myocardial infarction （AMI） and evaluate the relationship between dendritic cells（DCs） and them. Method： A total of 272 consecutive patients with AMI was analyzed. The incidence of AMI at six--hour intervals over 24 hours （4 periods） and four-month intervals in a year （4 seasons） were studied respectively. The function of DCs from the AMI patients and the healthy controls was determined. Result： The incidence of AMI in the period from January to March and from October to December was higher than those from April to June and from July to September. We also found that there was a circadian variation in the onset of AMI with a morning peak （6 am to 12 am）. Function of DCs revealed circadian and seasonal variation in both healthy controls and the AMI patients. The circadian and seasonal variation in incidence of AMI was correlated with the function of DCs. Conclusion： The incidence of AMI is higher in Winter and Spring than in Summer and Autumn with a morning peak from 6 am to 12 am. Immuno-inflammatory reaction mediated by DCs might play an important role in the circadian and seasonal variations of AMI.

关 键 词：心肌梗死 季节 炎症 树突状细胞 

分 类 号：R541.4[医药卫生—心血管疾病]