红景天对老年性痴呆大鼠行为学及海马区凋亡相关蛋白表达的影响  

Effects of Rhodiola Herb Against Behavior and the Expression of Apotosis-related Proteins in the Hippocampus of Alzheimer's Disease in Rats

作　　者：曹娟[1] 董联玲[2] 冀俊虎[1] 杨发明[1] 王健[1] 

机构地区：[1]山西医科大学,太原030001 [2]山西医科大学第二医院,太原030000

出　　处：《中国中医急症》2008年第11期1567-1569,共3页Journal of Emergency in Traditional Chinese Medicine

摘　　要：目的探讨红景天对老年性痴呆(AD)大鼠认知功能、海马CA1区Bcl-2、Bax蛋白表达的影响及其治疗阿尔茨海默病的可能作用机制。方法采用D-半乳糖+三氯化铝+氢溴酸东莨菪碱注射液法复制AD大鼠模型;采用Morris水迷宫法进行行为学检测,用免疫组化法检测海马CA1区Bcl-2、Bax蛋白的表达水平的变化。结果模型组与空白组相比,认知能力显著下降,Bcl-2/Bax比值下降;治疗组与模型组相比,认知能力显著改善,Bcl-2/Bax比值增加。结论红景天对AD大鼠脑神经细胞的保护作用可能是通过上调Bcl-2蛋白、下调Bax蛋白的表达,抑制细胞凋亡而实现,从而改善AD大鼠的学习记忆能力。Objective： To study the effects of Rhodiola herb against the behavior and expression of Bcl - 2 and Bax protein in hippocamps of Alzheimer＇ s disease in rats. Methods： AD model was formed by adopting the D - gal ＋ ALCL3 ＋ SCOP in SD rats . Cognitive abilities of rats were studied with the Morris water maze. The expression of Bcl - 2 and Bax protein in the hippocampus were studied with immunohistochemical staining. Results： AD model may decrease cognitive ability, the ratio of Bcl- 2/Bax in the hippocampus comes down. Rhodiola herb significant alleviated cognitive ability, the ratio of Bcl -2/ Bax rises. Conclusion： Rhodiola herb can inhibit apoptosis by increasing the expression of Bcl - 2 and reducing the expression of Bax protein in the hippocampus. Rhodiola herb may improve cognitive ability in AD rats.

关 键 词：老年性痴呆 红景天 认知功能 水迷宫 BEL-2 Bax 大鼠 

分 类 号：R285.5[医药卫生—中药学]