慢肾蛋白停对慢性肾炎湿热证尿表皮生长因子影响的实验研究  

The Experimental Study on Effect of Manshendanbaiting on the Leve of Urinary EGF in Damp-heat Chronic Glomerulonephritis

作　　者：张红梅[1] 陈雪功[1] 陈乐[2] 翟志敏[3] 王望九[1] 董昌武[1] 方向明[1] 张琼玉[2] 

机构地区：[1]安徽中医学院中医临床学院,合肥230038 [2]蚌埠医学院,蚌埠233030 [3]安徽省立医院,合肥230001

出　　处：《中国中医急症》2008年第11期1579-1580,共2页Journal of Emergency in Traditional Chinese Medicine

基　　金：安徽省教育厅自然科学资助项目(No.2005jq1100)

摘　　要：目的观察中药慢肾蛋白停对慢性肾炎湿热证尿表皮生长因子(EGF)变化的影响。方法采用手术摘除大鼠一侧肾脏加腹腔多次注射牛血清白蛋白(BSA)与大肠杆菌内毒素(LPS)及皮下多次注射完全弗氏佐剂复制慢性肾炎湿热证动物模型,并以慢肾蛋白停进行预防性治疗;测定尿EGF含量变化。结果慢肾蛋白停组尿EGF水平下降,与模型组和肾炎四味片组相比均有显著差异。结论慢肾蛋白停能够调节慢性肾炎湿热证肾内尿EGF的异常分泌,具有减轻肾组织病理损害的作用。Objective：To observe the effect of Chinese herbal medicine Manshendanbaiting（MDT） on the Leve of urinary EGF in damp -heat syndrome of chronic glomerulonephritis（CGN）. Methods： Model rats with damp -heat syndrome of CGN were induced by being cut one side kidney and injection of BSA, LPS and completed Freund＇ s adjuvant, then MDT prevented and treated them, and examined the Leve of urinary EGF. Results： The level of urinary EGF was decreased in MDT group, and MDT group compared with model and normal group, the difference was significant. Conclusion： MDT can adjust the abnormal level of renal EGF in damp - heat syndrome of CGN of rats, and improve renal function and pathological changes.

关 键 词：慢性肾炎 湿热证 表皮生长因子 大鼠 

分 类 号：R285.5[医药卫生—中药学]