溶剂法合成2-羟基-1-萘甲酸的工艺研究  

Study on Synthesis Process of 2-Hydroxy-1-naphthoic Acid by Solvent

作　　者：沈玉堂[1] 漆琳[1] 殷恒波[1] 刘于民[1] 姜廷顺[1] 

机构地区：[1]江苏大学化学化工学院,江苏镇江212013

出　　处：《精细化工中间体》2008年第5期37-39,共3页Fine Chemical Intermediates

基　　金：江苏大学青年基金资助项目(1283000077)

摘　　要：以β-萘酚和氢氧化钠为原料,正辛烷为溶剂,合成了2-羟基-1-萘甲酸,纯度达98%以上。通过正交实验研究了反应压力、反应温度和反应时间对收率的影响,确定了优化的工艺条件:反应压力0.8 MPa,反应温度90℃,反应时间8 h,该条件下收率达82.83%。2-Hydroxy-1-naphthoic acid was prepared from β-naphthol and sodium hydroxide in n-octane, and its purity was up to 98%. The effects of the reaction pressure, temperature and time on the yield of the product were investigated by orthogonal test, and the optimal conditions were obtained. Under the optimum conditions such as： reaction pressure 0.8 MPa, reaction temperature 90℃ and reaction time 8 h, the yield of the product was 82.83%.

关 键 词：2-羟基-1-萘甲酸 Kolbe-Schmitt反应 溶剂法 正交实验 正辛烷 

分 类 号：TQ245.4[化学工程—有机化工]