胸腹水染色体检查与间期细胞核观察鉴别诊断的临床意义  

Diagnosis of Malignant Pleural Effusion and Ascites by Combining Chromosome Analysis and Abnormal Nucleus Observation

作　　者：陈玉丽[1] 陈美云[1] 吴婷[1] 林其昌[1] 黄志华[1] 

机构地区：[1]福建医科大学

出　　处：《福建医科大学学报》1997年第3期283-286,共4页Journal of Fujian Medical University

摘　　要：目的研究胸腹水染色体检查与间期细胞核观察对恶性胸腹水鉴别诊断临床意义。方法１６１例胸腹水采用染色体常规制片，同时根据癌细胞核形态特征，检出异常细胞核。结果７６例恶性胸腹水染色体检查异常６６例，其中超二倍体６２例，标记染色体１９例；８５例良性胸腹水检查出现二倍体至四倍体染色体５例，其余为二倍体或未见分裂相；染色体检查特异性９４．１％，敏感性８６．８％，准确率９０．７％；染色体检查结合细胞核观察，敏感性可提高到９０．８％，准确率到９５．５％。结论在染色体检查分析同时，应观察间期细胞核形态，可以更加准确诊断良恶性。Objective\ To study the diagnosis signficance of pleural effusion and ascites with chromosome analysis and abnormal nucleus observation.\ Methods\ 161 cases(76 malignant cases and 85 benign cases) of pleural effusion and ascites were examined by chromosome analysis and checked up abnormal nucleus according to characteristics of cancer nucleus.\ Results\ Of 76 malignant cases,66 cases were found chromosomal abnormalities(62 cases hyperdipoid,19 cases marker chromosome). Among 85 benign cases,chromosome numbers of 5 cases ranged from diploid to tetraploid,and that of the others were diploid or not observed.\ Positivity rate of chromosome analysis was 94.1%,speciality rate of that was 86.8%, accuracy rate of that was 90.7%. When chromosome analysis and abnormal nucleus observation were used in combination,positivity rate and accuracy rate increased to 90.8% and 95.7% respectively.\ Conclusion\ It is more accurate to diagnose malignant or benign by combining chromosome analysis with abnormal nucleus observation.

关 键 词：胸水 腹水 染色体 细胞核 鉴别诊断 

分 类 号：R442.5[医药卫生—诊断学] R561.304[医药卫生—临床医学]