丹皮总甙对小鼠免疫性肝损伤的保护作用  

Protective effect of total glucosides of Mudan cortex on immunological liver injury in mice

作　　者：张安平[1] 沈玉先[1] 魏伟[1] 徐叔云[1] 

机构地区：[1]安徽医科大学临床药理研究所,合肥230032

出　　处：《中国药理学通报》1997年第5期435-437,共3页Chinese Pharmacological Bulletin

基　　金：安徽省科委八.五攻关研究项目

摘　　要：目的研究丹皮总甙（TGM）对小鼠免疫性肝损伤的保护作用。方法：小鼠分别尾ivBCG和LPS后，检测其血清ALT和AST活性、TPr含量及其脏器重量指数，并用硫代巴比妥酸法测其血清与肝组织中LPO含量。结果：TGM50、100mg·kg(－1)·d(－1)（ig），连用9d，可显著抑制小鼠血清ALT和AST活性，降低其血清与肝组织中LPO含量，并减轻其增大的脾脏重量指数。结论：TGM预防性给药对BCG＋LPS诱导的小鼠免疫性肝损伤具有一定的保护作用。To study the protective effect of total glucosides of Mudan cortex (TGM)on immunological liver injury in mice. METHODS: LPS was injected via the tail vein into micepretreated with BCG. The activities of serumALT and AST, the content of serum total pro-tien, and the weighing indexes of liver, spleenand thymus were tested respectively. The levelsof LPO in serum and hepatical tissues were measured by thiobarbituric acid method. RESULTS:TGM at doses of 50, 100 mg. kg 1. d--l, con-secutively 9 days, remarkably inhibited the activities of serum ALT and AST. and decreasedthe spleen--enlarged index and LPO levels inserum and hepatical tissues in mice. CONCLUSION: Pretreatment with TGM moderately prevents the liver damage induced by BCG+LPS inmICe.

关 键 词：丹皮总甙 卡介苗 脂多糖 肝损伤 

分 类 号：R285.5[医药卫生—中药学]