依扑拉芬的抗维甲酸引起大鼠骨质疏松作用  

Actions of ipriflavone on vitamin A acid-induced osteoporosis in rats

作　　者：葛志东[1] 周爱武[1] 王迎新[2] 李卫平[1] 李康 王斌[1] 姚余有[1] 陈敏珠[1] 

机构地区：[1]安徽医科大学临床药理研究所,合肥230032 [2]安徽省卫生干部进修学校,合肥230001 [3]安徽中医学院药学系

出　　处：《中国药理学通报》1997年第5期447-449,共3页Chinese Pharmacological Bulletin

摘　　要：目的研究国产依扑拉芬对大鼠骨质疏松的影响。方法：使用维甲酸诱导大鼠骨质疏松。结果：依扑拉芬显著降低维甲酸升高的尿Ca(2+)排泄量，显著升高血Ca(2+)浓度。逆转维甲酸降低的血pi浓度，剂量依赖性增加维甲酸降低的股骨干骺端和骨干的平均骨密度，显著升高维甲酸降低的股骨Ca(2+)和Pi含量。结论：依扑拉芬对维甲酸引起的大鼠骨质疏松具有良好的防治作用。Effect of ipriflavone on vita-min A acid-induced osteoporosis in rats wasstudied. METHODS: Vitamin A acid was usedto induce osteoporosis in rats. RESUCTS: Vita-min A acid 70 mg. kg-1. d-1 markedly decreased the calcium and phosphorus contents offemora, and serum phosphorus, and significantly increased uninary calcium. Microdensitometrical analysis of roentgenography indicatedthat vitamin A acid 70 mg. kg-1. d-1 noticeablyreduced the density of both distal metaphysesand diaphyses of femora. When ipriflavone atthe doses of 50, 100, 200 mg. kg-1. d-1 wasintragastrically administered to rats, it wasfound that the above-mentioned changes inducedby vitamin A acid were dose-dependently inhibited. In addition, ipriflavone at the doses of 50.100, 200 mg. kg-1'. d-1 showed marked elevating effect on serum calcium in rats. CONCLUSION: Ipriflavone is effective in preventing andtreating osteoporosis in rats induced by vitaminA acid.

关 键 词：依扑拉芬 维甲酸 骨质疏松 药物疗法 

分 类 号：R982[医药卫生—药品] R681.05[医药卫生—药学]