SOD与别嘌呤醇对流感病毒感染致小鼠病损的保护作用  

Protective effect of SOD and allopurinol on influenza induced pathogenesis in mice

作　　者：韩娜 张卫东[1,2] 徐贝力 王美岭[1,2] 李晓冰 刘斌[1,2] 

机构地区：[1]山东医科院基础医学研究所 [2]山东省医学科学院

出　　处：《中国药理学通报》1997年第4期351-354,共4页Chinese Pharmacological Bulletin

摘　　要：目的：探讨超氧化物歧化酶（ＳｕｐｅｒｏｘｉｄｅＤｉｓｍｕ－ｔａｓｅ，ＳＯＤ）、黄嘌呤氧化酶抑制剂别嘌呤醇在流感病毒感染小鼠致病中的保护作用。方法：流感病毒Ａ／ＦＭ１／１／４７（Ｈ１Ｎ１）鼠适应株，鼻腔内接种感染小鼠，分别于病毒感染后的不同时间对各用药组小鼠取肺进行检测。结果：ＳＯＤ和别嘌呤醇可显著降低小鼠支气管肺泡灌洗液中氧自由基水平和肺组织中黄嘌呤氧化酶活性，明显减轻小鼠肺组织损伤，从而使小鼠的生存率提高。ＳＯＤ与抗病毒药物三氮唑核苷联合应用，其保护作用优于单一用药。结论：ＳＯＤ、别嘌呤醇对小鼠的保护作用是通过对氧自由基的清除和产生的阻断，减轻了其组织损伤来实现的。AIM: To investigate the protective effect of superoxide dismutase (SOD) and allopurinol (an xanthine oxidase inhibitor) on influenza induced pathogenesis in mice. METHODS: The influenza A/FM1/1/47(H 1N 1) adapted to mice by nostril inoculation. Lung tissues from the mice of drug groups were studied in different times after virus infection. RESULTS: SOD and allopurinol could remarkably reduce oxygen free radical levels of the bronchalveolar lavage fluid and xanthine oxidase activities in lung tissues, and alleviated marked lung tissue injury, and raised survival rates. The protective effect of combination of SOD and virazole excelled the single. CONCLUSIONS: The protective effect of SOD and allopurinol in mice alleviated lung injury by elimination and prevention of oxygen free radicals.

关 键 词：超氧化物歧化酶 别嘌呤醇 流感病毒 

分 类 号：R978.7[医药卫生—药品] R373.1[医药卫生—药学]