松果腺与细胞免疫的关系及白芍总甙的作用  

The relationship of between the pineal gland and cell immunity and the influence of TGP

作　　者：许杜娟[1,2,3] 魏伟[1,2,3] 徐叔云[1,2,3] 

机构地区：[1]安徽医科大学临床药理研究所 [2]合肥市第二人民医院药剂科 [3]安徽医科大学

出　　处：《中国药理学通报》1997年第4期372-374,共3页Chinese Pharmacological Bulletin

摘　　要：目的：观察松果腺功能低下大鼠的细胞免疫的变化及白芍总甙（ＴＧＰ）的作用。方法：主要应用傍晚腹腔注射普萘洛尔或大鼠双侧颈上神经节切除造成松果腺功能低下的模型。结果：下午４：００腹腔注射普萘洛尔（１５ｍｇ·ｋｇ－１·ｄ－１×７ｄ）可引起Ｔ、Ｂ淋巴细胞转化率降低、ＴＧＰ（２０ｍｇ·ｋｇ－１·ｄ－１，ｉｐ或５０ｍｇ·ｋｇ－１·ｄ－１ｐｏ）能使普萘洛尔降低的Ｔ、Ｂ淋巴细胞免疫功能恢复正常；双侧颈上神经节切除造成大鼠胸腺及脾淋巴细胞的致分裂素反应降低，ＩＬ－２生成减少、ＴＧＰ（２０ｍｇ·ｋｇ－１·ｄ－１ｉｐ或５０ｍｇ·ｋｇ－１·ｄ－１ｐｏ）可反转双侧颈上神经节切除的作用。结论：ＴＧＰ的免疫调节作用与松果腺有关。AIM:The effects of evening administration propranolol and SCGX on immunity system were observed, meanwhile influence of TGP on the pineal gland was studied. METHODS: A the pineal gland malfunctional model was found by peritoncal injection of propranolo(4:00 pm, 15 mg·kg -1 ·d -1 ,7 d) and SCGX. TGP (20 mg·kg -1 ·d -1 ,ip or or 50 mg·kg -1 ·d -1 ,7 d po) was used respective. RESULTS: Propranolo could decrease proliferative responses of lymphocytes to ConA and LPS. TGP could antagonize the effects of propranolol on immunity system. Following SCGX the proliferation of T and B cell was inhibited and IL 2 prodution was decreased. TGP could resume some immune function. CONCLUTION: It suggested that the TGP could modulate the immune function through the pineal gland.

关 键 词：松果腺 白芍总甙 细胞免疫 

分 类 号：R284.1[医药卫生—中药学] R392.12[医药卫生—中医学]