新鲜冰冻血浆输入量对辅助治疗DIC效果的观察  

Effects of fresh frozen plasma perfusion in different amounts as adjuvant therapy for disseminated intravascular coagulation

作　　者：陈燕[1] 梁晓林[1] 

机构地区：[1]首都医科大学附属北京友谊医院输血科,北京100050

出　　处：《中国急救复苏与灾害医学杂志》2008年第11期682-683,共2页China Journal of Emergency Resuscitation and Disaster Medicine

摘　　要：目的观察不同新鲜冰冻血浆输入量对于辅助治疗弥散性血管内凝血(DIC)的效果。方法内科急诊确诊的37例DIC患者,男31例,女6例;年龄38～79岁,分别输入新鲜冰冻血浆(FFP)200ml(11例),400m(l16例),或600ml(10例),观察血浆输入前后患者D-二聚体(D-D)值的变化。结果3组于输入FFP后12hD-D值均降低,与治疗前比较差异均有统计学意义(均P<0.05)。600ml组的D-D值下降率为100.00%,显著高于400ml组和200ml组(分别为75.00%和72.73%,均P<0.05),但200ml组和400ml组间的D-D值下降率间差异无统计学意义(P>0.05)。结论治疗DIC过程中输入新鲜冰冻血浆有助于降低D-D值,且足量补充比少量输入新鲜冰冻血浆的效果好。Objective To observe the effects of fresh frozen plasma （FFP） perfusion in different amounts as adjuvant therapy in treatment of disseminated intravascular coagulation （DIC）. Methods Thirty-seven patients with DIC diagnosed in the Department of Emergency, 31 males and 6 females, aged 39-79, underwent perfusion of FFP of the volumes 200 ml （n=11）, 400 ml （n=16）, or 600 ml （n=10） respectively according to the serum D-D levels before treratment. Serum D-D value eas detected before treatment and 12 hours after FFP perfusion. Results The serum D-D values of the 3 groups all significantly decreaseds 12 hours after FFP perfusion compared to those before treatment （all P〈0.05）. The D-D value decrease rate of the 600 ml FFP group was 100%, significantly higher than those of the 400 ml and 200 ml FFP groups （75.00% and 72.73% respectively, both P〈0.05）. However, there was no significant difference ibn the DD-value decrease rate between the FFP 400 ml and FFP 200 ml groups （P〉 0.05）. Conclusion FFP perfusion helps reduce the serum D-D value in the DIC patients. Perfusion of enough amount of FFP is more effective.

关 键 词：弥散性血管内凝血 新鲜冰冻血浆 D-二聚体 

分 类 号：R457.1[医药卫生—治疗学]